The association of DNA Repair with breast cancer risk in women. A comparative observational study.

Julie Dutil's picture
TitleThe association of DNA Repair with breast cancer risk in women. A comparative observational study.
Publication TypeJournal Article
Year of Publication2012
AuthorsMatta, J, Echenique, M, Negron, E, Morales, L, Vargas, W, Gaetan, FSánchez, Lizardi, ERamírez, Torres, A, Rosado, JOrtiz, Bolaños, G, Cruz, JGonzález, Laboy, J, Barnes, R, Medina, SSantiago, Romero, A, Martinez, R, Dutil, J, Suarez, E, Alvarez-Garriga, C, Bayona, M
JournalBMC Cancer
Volume12
Pagination490
Date Published2012
ISSN1471-2407
KeywordsAdult, Breast Neoplasms, Case-Control Studies, DNA Damage, DNA Repair, Female, Genetic Markers, Humans, Logistic Models, Middle Aged, Puerto Rico, Reproducibility of Results, Risk Factors, ROC Curve, Sensitivity and Specificity, Young Adult
Abstract

BACKGROUND: Previous studies have found a link between a low DNA repair capacity (DRC) level and increased cancer risk. Our aim was to assess the statistical association of DRC level and breast cancer (BC) using a case-control epidemiological study in a Hispanic community.

METHODS: We conducted a comparative observational study to assess the validity of DRC in detecting BC in 824 women throughout Puerto Rico. Over a 6-year period, we compared 285 women newly diagnosed with BC to 539 without BC. DRC levels were measured in lymphocytes by means of a host-cell reactivation assay. We assessed the sensitivity, specificity, and association using the receiver operating characteristic curve analysis. Multiple logistic regression-adjusted odds ratios were estimated with 95% confidence level to measure the strength of the association of DRC and BC after adjusting for all confounders simultaneously.

RESULTS: Compared to women without cancer, women with BC showed an average decrease of 60% in their DRC levels (p

CONCLUSIONS: Our results support the usefulness of DRC level as a measure of BC risk. Additional studies in other populations are needed to further verify its usefulness.

DOI10.1186/1471-2407-12-490
Alternate JournalBMC Cancer
PubMed ID23088658
PubMed Central IDPMC3572436
Grant List5U56 CA126379-05 / CA / NCI NIH HHS / United States
G12 MD007579 / MD / NIMHD NIH HHS / United States
G12 RR003050 / RR / NCRR NIH HHS / United States
S06 GM008239 / GM / NIGMS NIH HHS / United States
S06 GM008239-20 / GM / NIGMS NIH HHS / United States
SC1 CA157250 / CA / NCI NIH HHS / United States
SC1 CA182846 / CA / NCI NIH HHS / United States
SC1 ISA157250-01 / / PHS HHS / United States
U56 CA126379 / CA / NCI NIH HHS / United States