|Title||The association of DNA Repair with breast cancer risk in women. A comparative observational study.|
|Publication Type||Journal Article|
|Year of Publication||2012|
|Authors||Matta, J, Echenique, M, Negron, E, Morales, L, Vargas, W, Gaetan, FSánchez, Lizardi, ERamírez, Torres, A, Rosado, JOrtiz, Bolaños, G, Cruz, JGonzález, Laboy, J, Barnes, R, Medina, SSantiago, Romero, A, Martinez, R, Dutil, J, Suarez, E, Alvarez-Garriga, C, Bayona, M|
|Keywords||Adult, Breast Neoplasms, Case-Control Studies, DNA Damage, DNA Repair, Female, Genetic Markers, Humans, Logistic Models, Middle Aged, Puerto Rico, Reproducibility of Results, Risk Factors, ROC Curve, Sensitivity and Specificity, Young Adult|
BACKGROUND: Previous studies have found a link between a low DNA repair capacity (DRC) level and increased cancer risk. Our aim was to assess the statistical association of DRC level and breast cancer (BC) using a case-control epidemiological study in a Hispanic community.
METHODS: We conducted a comparative observational study to assess the validity of DRC in detecting BC in 824 women throughout Puerto Rico. Over a 6-year period, we compared 285 women newly diagnosed with BC to 539 without BC. DRC levels were measured in lymphocytes by means of a host-cell reactivation assay. We assessed the sensitivity, specificity, and association using the receiver operating characteristic curve analysis. Multiple logistic regression-adjusted odds ratios were estimated with 95% confidence level to measure the strength of the association of DRC and BC after adjusting for all confounders simultaneously.
RESULTS: Compared to women without cancer, women with BC showed an average decrease of 60% in their DRC levels (p
CONCLUSIONS: Our results support the usefulness of DRC level as a measure of BC risk. Additional studies in other populations are needed to further verify its usefulness.
|Alternate Journal||BMC Cancer|
|PubMed Central ID||PMC3572436|
|Grant List||5U56 CA126379-05 / CA / NCI NIH HHS / United States |
G12 MD007579 / MD / NIMHD NIH HHS / United States
G12 RR003050 / RR / NCRR NIH HHS / United States
S06 GM008239 / GM / NIGMS NIH HHS / United States
S06 GM008239-20 / GM / NIGMS NIH HHS / United States
SC1 CA157250 / CA / NCI NIH HHS / United States
SC1 CA182846 / CA / NCI NIH HHS / United States
SC1 ISA157250-01 / / PHS HHS / United States
U56 CA126379 / CA / NCI NIH HHS / United States