DNA repair and breast carcinoma susceptibility in women.

Jaime Matta's picture
TitleDNA repair and breast carcinoma susceptibility in women.
Publication TypeJournal Article
Year of Publication2004
AuthorsRamos, JM, Ruiz, A, Colen, R, Lopez, ID, Grossman, L, Matta, JL
JournalCancer
Volume100
Issue7
Pagination1352-7
Date Published2004 Apr 1
ISSN0008-543X
KeywordsAdult, Aged, Breast Neoplasms, Carcinoma, Ductal, Breast, Case-Control Studies, DNA Repair, Female, Humans, Logistic Models, Luciferases, Lymphocytes, Middle Aged, Questionnaires, Risk Factors
Abstract

BACKGROUND: Breast carcinoma is the most common cancer and the second leading cause of cancer-related deaths among women. The disease represents approximately 31% of all cancers in Puerto Rican women. Several DNA repair pathways are involved in preventing carcinogenesis. The current study evaluated the hypothesis that a reduced DNA repair capacity (DRC) is a susceptibility factor for breast carcinoma.

METHODS: A retrospective case-control clinical study was performed to compare age-matched DRC in 33 women with histopathologically confirmed breast carcinoma (cases) and 47 cancer-free women (controls). DRC was measured using a host cell reactivation assay with a luciferase reporter gene and then transfected into human peripheral lymphocytes. A questionnaire was used to solicit breast carcinoma risk factors.

RESULTS: Women with breast carcinoma had a mean DRC of 5.6% +/- 0.5 standard error of the mean (SEM). Cancer cases had a 36% reduction (P

CONCLUSIONS: The findings supported the hypothesis that a low DRC is a susceptibility factor for breast carcinoma. A 1% decrease in DRC corresponded to a 22% increase in breast carcinoma risk. To the authors' knowledge, the current study was the first to directly determine the DRC of women with breast carcinoma. Because DRC is an independent risk factor for breast carcinoma, the DRC of women may be a useful marker in predicting susceptibility.

DOI10.1002/cncr.20135
Alternate JournalCancer
PubMed ID15042667
Grant List2 G12 RR A1030 50-16 / RR / NCRR NIH HHS / United States
2G12 RR03050-18 / RR / NCRR NIH HHS / United States