Adenosine A-Dopamine D Receptor Heteromers Control the Excitability of the Spinal Motoneuron.
Submitted by Gian Carlo Molina-Castro, Ph.D. on
Title | Adenosine A-Dopamine D Receptor Heteromers Control the Excitability of the Spinal Motoneuron. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Rivera-Oliver, M, Moreno, E, Álvarez-Bagnarol, Y, Ayala-Santiago, C, Cruz-Reyes, N, Molina-Castro, GCarlo, Clemens, S, Canela, EI, Ferré, S, Casadó, V, Díaz-Ríos, M |
Journal | Mol Neurobiol |
Date Published | 2018 May 24 |
ISSN | 1559-1182 |
Abstract | While the role of the ascending dopaminergic system in brain function and dysfunction has been a subject of extensive research, the role of the descending dopaminergic system in spinal cord function and dysfunction is just beginning to be understood. Adenosine plays a key role in the inhibitory control of the ascending dopaminergic system, largely dependent on functional complexes of specific subtypes of adenosine and dopamine receptors. Combining a selective destabilizing peptide strategy with a proximity ligation assay and patch-clamp electrophysiology in slices from male mouse lumbar spinal cord, the present study demonstrates the existence of adenosine A-dopamine D receptor heteromers in the spinal motoneuron by which adenosine tonically inhibits D receptor-mediated signaling. A-D receptor heteromers play a significant control of the motoneuron excitability, represent main targets for the excitatory effects of caffeine in the spinal cord and can constitute new targets for the pharmacological therapy after spinal cord injury, motor aging-associated disorders and restless legs syndrome. |
DOI | 10.1007/s12035-018-1120-y |
Alternate Journal | Mol. Neurobiol. |
PubMed ID | 29797183 |
Grant List | SAF2014-54840-R / / Ministerio de Economía y Competitividad / 8G12-MD007600 / / National Institute on Minority Health and Health Disparities / Intramural Funds / / National Institute on Drug Abuse / R25 GM061151 / GM / NIGMS NIH HHS / United States 2014-SGR-1236 / / Generalitat de Catalunya / P20 GM103642 / GM / NIGMS NIH HHS / United States G12 MD007600 / MD / NIMHD NIH HHS / United States 1337284 / / Division of Biological Infrastructure / 1P20GM103642 / / National Institute of General Medical Sciences / |