The association of DNA Repair with breast cancer risk in women. A comparative observational study.
Submitted by Julie Dutil on
Title | The association of DNA Repair with breast cancer risk in women. A comparative observational study. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Matta, J, Echenique, M, Negron, E, Morales, L, Vargas, W, Gaetan, FSánchez, Lizardi, ERamírez, Torres, A, Rosado, JOrtiz, Bolaños, G, Cruz, JGonzález, Laboy, J, Barnes, R, Medina, SSantiago, Romero, A, Martinez, R, Dutil, J, Suarez, E, Alvarez-Garriga, C, Bayona, M |
Journal | BMC Cancer |
Volume | 12 |
Pagination | 490 |
Date Published | 2012 |
ISSN | 1471-2407 |
Keywords | Adult, Breast Neoplasms, Case-Control Studies, DNA Damage, DNA Repair, Female, Genetic Markers, Humans, Logistic Models, Middle Aged, Puerto Rico, Reproducibility of Results, Risk Factors, ROC Curve, Sensitivity and Specificity, Young Adult |
Abstract | BACKGROUND: Previous studies have found a link between a low DNA repair capacity (DRC) level and increased cancer risk. Our aim was to assess the statistical association of DRC level and breast cancer (BC) using a case-control epidemiological study in a Hispanic community. METHODS: We conducted a comparative observational study to assess the validity of DRC in detecting BC in 824 women throughout Puerto Rico. Over a 6-year period, we compared 285 women newly diagnosed with BC to 539 without BC. DRC levels were measured in lymphocytes by means of a host-cell reactivation assay. We assessed the sensitivity, specificity, and association using the receiver operating characteristic curve analysis. Multiple logistic regression-adjusted odds ratios were estimated with 95% confidence level to measure the strength of the association of DRC and BC after adjusting for all confounders simultaneously. RESULTS: Compared to women without cancer, women with BC showed an average decrease of 60% in their DRC levels (p < 0.001). Validity of the association of DRC as a measure of BC risk showed a sensitivity of 83.2% and specificity of 77.6% (p < 0.0001). CONCLUSIONS: Our results support the usefulness of DRC level as a measure of BC risk. Additional studies in other populations are needed to further verify its usefulness. |
DOI | 10.1186/1471-2407-12-490 |
Alternate Journal | BMC Cancer |
PubMed ID | 23088658 |
PubMed Central ID | PMC3572436 |
Grant List | 5U56 CA126379-05 / CA / NCI NIH HHS / United States G12 MD007579 / MD / NIMHD NIH HHS / United States G12 RR003050 / RR / NCRR NIH HHS / United States S06 GM008239 / GM / NIGMS NIH HHS / United States S06 GM008239-20 / GM / NIGMS NIH HHS / United States SC1 CA157250 / CA / NCI NIH HHS / United States SC1 CA182846 / CA / NCI NIH HHS / United States SC1 ISA157250-01 / / PHS HHS / United States U56 CA126379 / CA / NCI NIH HHS / United States |