|Title||DNA repair and breast carcinoma susceptibility in women.|
|Publication Type||Journal Article|
|Year of Publication||2004|
|Authors||Ramos, JM, Ruiz, A, Colen, R, Lopez, ID, Grossman, L, Matta, JL|
|Date Published||2004 Apr 1|
|Keywords||Adult, Aged, Breast Neoplasms, Carcinoma, Ductal, Breast, Case-Control Studies, DNA Repair, Female, Humans, Logistic Models, Luciferases, Lymphocytes, Middle Aged, Questionnaires, Risk Factors|
BACKGROUND: Breast carcinoma is the most common cancer and the second leading cause of cancer-related deaths among women. The disease represents approximately 31% of all cancers in Puerto Rican women. Several DNA repair pathways are involved in preventing carcinogenesis. The current study evaluated the hypothesis that a reduced DNA repair capacity (DRC) is a susceptibility factor for breast carcinoma.
METHODS: A retrospective case-control clinical study was performed to compare age-matched DRC in 33 women with histopathologically confirmed breast carcinoma (cases) and 47 cancer-free women (controls). DRC was measured using a host cell reactivation assay with a luciferase reporter gene and then transfected into human peripheral lymphocytes. A questionnaire was used to solicit breast carcinoma risk factors.
RESULTS: Women with breast carcinoma had a mean DRC of 5.6% +/- 0.5 standard error of the mean (SEM). Cancer cases had a 36% reduction (P
CONCLUSIONS: The findings supported the hypothesis that a low DRC is a susceptibility factor for breast carcinoma. A 1% decrease in DRC corresponded to a 22% increase in breast carcinoma risk. To the authors' knowledge, the current study was the first to directly determine the DRC of women with breast carcinoma. Because DRC is an independent risk factor for breast carcinoma, the DRC of women may be a useful marker in predicting susceptibility.
|Grant List||2 G12 RR A1030 50-16 / RR / NCRR NIH HHS / United States |
2G12 RR03050-18 / RR / NCRR NIH HHS / United States