Fertilization.

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TitleFertilization.
Publication TypeJournal Article
Year of Publication2013
AuthorsMarcello, MR, Singaravelu, G, Singson, A
JournalAdv Exp Med Biol
Volume757
Pagination321-50
Date Published2013
ISSN0065-2598
KeywordsAnimals, Caenorhabditis elegans, Fertilization
Abstract

Fertilization-the fusion of gametes to produce a new organism-is the culmination of a multitude of intricately regulated cellular processes. In Caenorhabditis elegans, fertilization is highly efficient. Sperm become fertilization competent after undergoing a maturation process during which they become motile, and the plasma membrane protein composition is reorganized in preparation for interaction with the oocyte. The highly specialized gametes begin their interactions by signaling to one another to ensure that fertilization occurs when they meet. The oocyte releases prostaglandin signals to help guide the sperm to the site of fertilization, and sperm secrete a protein called major sperm protein (MSP) to trigger oocyte maturation and ovulation. Upon meeting one another in the spermatheca, the sperm and oocyte fuse in a specific and tightly regulated process. Recent studies are providing new insights into the molecular basis of this fusion process. After fertilization, the oocyte must quickly transition from the relative quiescence of oogenesis to a phase of rapid development during the cleavage divisions of early embryogenesis. In addition, the fertilized oocyte must prevent other sperm from fusing with it as well as produce an eggshell for protection during external development. This chapter will review the nature and regulation of the various cellular processes of fertilization, including the development of fertilization competence, gamete signaling, sperm-oocyte fusion, the oocyte to embryo transition, and production of an eggshell to protect the developing embryo.

DOI10.1007/978-1-4614-4015-4_11
Alternate JournalAdv. Exp. Med. Biol.
PubMed ID22872482
Grant ListGM093854 / GM / NIGMS NIH HHS / United States
R01HD054681-06 / HD / NICHD NIH HHS / United States