Staff Scientist Laboratory of Systems Biology, NIAID (deadline: October 31)

Mónica Ivelisse Feliú-Mójer's picture

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The National Institute of Allergy and Infectious Diseases (NIAID) conducts and supports a global program of research to better understand, treat, and ultimately prevent infectious, immunologic, and allergic diseases. NIAID's Laboratory of Systems Biology (LSB) Signaling Systems Unit (SSU) has an opening for a staff scientist with expertise in experimental systems biology and innate immune signaling. The response of innate immune cells to pathogenic stimuli is mediated by a wide range of pattern recognition receptors (PRRs) that engage unique invariant molecular components of bacteria, viruses, or parasites. PRR activation leads, through cell signaling and transcriptional upregulation, to a program of cellular responses that orchestrate the host response to infection. Our laboratory seeks to understand the principles of signal processing used by innate immune cells to integrate complex inputs and evoke specific responses. We use high-throughput genome-scale technologies (such as siRNA screening and profiling of RNA expression and protein modification) to broadly characterize the cellular response to pathogenic stimuli. Our lab is part of an integrated systems biology program at NIAID that seeks to foster collaboration between experimental and computational scientists, with the shared goal of developing quantitative models describing host-pathogen interactions. The successful applicant will have primary responsibility for managing the RNAi screening activities of the laboratory, including management of large reagent sets and siRNA libraries, screening equipment maintenance and operation, screen data handling, and interfacing with informatics colleagues to facilitate data analysis. Experience in developing mammalian cell-based reporter assays, particularly the use of fluorescent signaling reporters for high-content imaging applications, would be desirable. Additionally, there will be opportunity for the successful applicant to design and implement projects that take an integrative approach to understanding host-pathogen interactions, incorporating data from complementary approaches such as transcriptomics and phosphoprotein profiling and leveraging additional resources from other LSB research groups. The position requires a Ph.D. and at least three years of postdoctoral experience, a strong record of productive research supported by publications, and proven ability to work in a group setting, preferably with supervisory experience. For more information about LSB, visit www.niaid.nih.gov/labsandresources/labs/aboutlabs/lsb. To apply, send curriculum vitae, bibliography, three letters of recommendation, and a short statement about your skill set, including how you see applying integrative screening approaches to better understand host-pathogen interactions (no more than two pages) by October 31, 2011, to Iain Fraser, Ph.D., Chief, SSU, LSB, NIAID/NIH/HHS, 4 Memorial Drive, Building 4, Room 228A, Bethesda, MD 20892-0430 or fraseri@niaid.nih.gov. Learn more about NIAID and how you can play a role in this exciting and dynamic research organization: Visit us on the Web: http://www.niaid.nih.gov/careers/bl5; Follow us on Twitter: Twitter.com/NIAIDCareers; Become a fan on Facebook: Facebook.com/niaid.nih. HHS, NIH, and NIAID are equal opportunity employers.

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