The Chemical Biology Laboratory (CBL), Molecular Discovery Program (MDP), Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS) is accepting applications for the position of Tenure Track Investigator to develop an independent research program addressing problems at the interface of chemistry and biology. This intramural position is similar to that of a tenure-track assistant professor in academia. Three distinct areas of chemical biology are of particular interest: synthetic organic chemistry developing novel methodology towards the preparation of complex biologically active molecules; chemistry-based development and implementation of novel imaging tools; small molecule control of cell fate. Individual will establish a dynamic, collaborative program to develop and apply chemical methods and tools that define and manipulate the biological processes that impact cancer and/or AIDS. Additionally, an Investigator is expected to establish an internationally recognized program and direct a research group composed of postdoctoral fellows and technicians. Candidates must possess a Ph.D. in chemistry or related physical science. This search is directed at the tenure track level. The position is located at the NCI-Frederick, Md., campus. This location offers state-of-the-art chemical biology laboratories as well as core facilities including mass spectrometry; NMR spectroscopy; protein expression and proteomics; electron, optical and small animal imaging and other advanced technologies. Incumbent will be provided with laboratory space, research equipment, staff support, and an annual supply budget. Consideration of applicants will begin October 3, 2011 and will continue until the position is filled. Salary is competitive and is commensurate with experience and full benefits (including retirement, health insurance, life insurance, and a Thrift Savings Plan). This position is not restricted to U.S. citizens. To apply, please submit a cover letter, curriculum vitae, description of research plans (~ 5 pages), and arrange to have 3 letters of recommendation sent to: Ms. Deanna Dougherty, Administrative Officer, NCI-Frederick, P.O. Box B, Bldg. 578/27, Frederick, MD 21702-1201, Tel. 301-846-5199, Fax 301-846-6053, E-mail: CBLTenureTrackApps@mail.nih.gov. PDF files are encouraged. This position is subject to a background investigation. The NIH is dedicated to building a diverse community in its training and employment programs. DHHS, NIH, and NCI are Equal Opportunity Employers.