The genetics and cell biology of fertilization.
Submitted by Matthew Marcello on
Title | The genetics and cell biology of fertilization. |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Geldziler, BD, Marcello, MR, Shakes, DC, Singson, A |
Journal | Methods Cell Biol |
Volume | 106 |
Pagination | 343-75 |
Date Published | 2011 |
ISSN | 0091-679X |
Keywords | Animals, Caenorhabditis elegans, Cell Biology, Female, Fertility, Fertilization, Gametogenesis, Infertility, Male, Mutation, Oocytes, Sperm Motility, Spermatozoa |
Abstract | Although the general events surrounding fertilization in many species are well described, the molecular underpinnings of fertilization are still poorly understood. Caenorhabditis elegans has emerged as a powerful model system for addressing the molecular and cell biological mechanism of fertilization. A primary advantage is the ability to isolate and propagate mutants that effect gametes and no other cells. This chapter provides conceptual guidelines for the identification, maintenance, and experimental approaches for the study fertility mutants. |
DOI | 10.1016/B978-0-12-544172-8.00013-X |
Alternate Journal | Methods Cell Biol. |
PubMed ID | 22118284 |
PubMed Central ID | PMC3275088 |
Grant List | R01 HD054681 / HD / NICHD NIH HHS / United States R01 HD054681-10 / HD / NICHD NIH HHS / United States R15 GM060359-02 / GM / NIGMS NIH HHS / United States |