Genome wide evolutionary analyses reveal serotype specific patterns of positive selection in selected Salmonella serotypes

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TitleGenome wide evolutionary analyses reveal serotype specific patterns of positive selection in selected Salmonella serotypes
Publication TypeJournal Article
Year of Publication2009
AuthorsSoyer, Y, Orsi, RH, Rodriguez-Rivera, LD, Sun, Q, Wiedmann, M
JournalBMC Evolutionary Biology
Volume9
Issuei
Pagination264 - 264
Date Published2009///
KeywordsBacterial, bacterial genetics, comparative genomic hybridization, DNA, evolution, Genes, genetic, Genome, molecular, recombination, Salmonella, salmonella classification, salmonella genetics, selection, Sequence Analysis, serotyping
AbstractBackground: The bacterium Salmonella enterica includes a diversity of serotypes that cause disease in humans and different animal species. Some Salmonella serotypes show a broad host range, some are host restricted and exclusively associated with one particular host, and some are associated with one particular host species, but able to cause disease in other host species and are thus considered "host adapted". Five Salmonella genome sequences, representing a broad host range serotype (Typhimurium), two host restricted serotypes (Typhi two genomes and Paratyphi) and one host adapted serotype (Choleraesuis) were used to identify core genome genes that show evidence for recombination and positive selection. Results: Overall, 3323 orthologous genes were identified in all 5 Salmonella genomes analyzed. Use of four different methods to assess homologous recombination identified 270 genes that showed evidence for recombination with at least one of these methods (false discovery rate FDR
URLhttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2784778&tool=pmcentrez&rendertype=abstract