Neuroinflammation in Retinitis Pigmentosa, Diabetic Retinopathy, and Age-Related Macular Degeneration: A Minireview.
Submitted by Cristhian J Ildefonso on
Title | Neuroinflammation in Retinitis Pigmentosa, Diabetic Retinopathy, and Age-Related Macular Degeneration: A Minireview. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Massengill, MT, Ahmed, CM, Lewin, AS, Ildefonso, CJ |
Journal | Adv Exp Med Biol |
Volume | 1074 |
Pagination | 185-191 |
Date Published | 2018 |
ISSN | 0065-2598 |
Abstract | The eye is an immuno-privileged organ. However, certain diseases such as uveitis are intrinsically linked to inflammation. In several retinal degenerative diseases, there is a unique damage at the onset of the disease, but evidence suggests that chronic and low-grade inflammatory processes play an important role in their progression. Studies have identified similar signaling pathways and changes in resident immune cells within the retina among these diseases. Herein, we will discuss some of these studies and propose how understanding this inflammatory response could aid in the development of therapies. |
DOI | 10.1007/978-3-319-75402-4_23 |
Alternate Journal | Adv. Exp. Med. Biol. |
PubMed ID | 29721943 |
Grant List | F30 EY027163 / EY / NEI NIH HHS / United States P30 EY001583 / EY / NEI NIH HHS / United States R01 EY026268 / EY / NEI NIH HHS / United States |