Neuroinflammation in Retinitis Pigmentosa, Diabetic Retinopathy, and Age-Related Macular Degeneration: A Minireview.

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TitleNeuroinflammation in Retinitis Pigmentosa, Diabetic Retinopathy, and Age-Related Macular Degeneration: A Minireview.
Publication TypeJournal Article
Year of Publication2018
AuthorsMassengill, MT, Ahmed, CM, Lewin, AS, Ildefonso, CJ
JournalAdv Exp Med Biol
Volume1074
Pagination185-191
Date Published2018
ISSN0065-2598
Abstract

The eye is an immuno-privileged organ. However, certain diseases such as uveitis are intrinsically linked to inflammation. In several retinal degenerative diseases, there is a unique damage at the onset of the disease, but evidence suggests that chronic and low-grade inflammatory processes play an important role in their progression. Studies have identified similar signaling pathways and changes in resident immune cells within the retina among these diseases. Herein, we will discuss some of these studies and propose how understanding this inflammatory response could aid in the development of therapies.

DOI10.1007/978-3-319-75402-4_23
Alternate JournalAdv. Exp. Med. Biol.
PubMed ID29721943
Grant ListF30 EY027163 / EY / NEI NIH HHS / United States
P30 EY001583 / EY / NEI NIH HHS / United States
R01 EY026268 / EY / NEI NIH HHS / United States