Parthenolide prevents the expression of cocaine-induced withdrawal behavior in planarians.

Submitted by Oné R Pagán on

Oné R Pagán's picture
PDF versionPDF version
TitleParthenolide prevents the expression of cocaine-induced withdrawal behavior in planarians.
Publication TypeJournal Article
Year of Publication2008
AuthorsRowlands, AL, Pagán, OR
JournalEur J Pharmacol
Volume583
Issue1
Pagination170-2
Date Published2008 Mar 31
ISSN0014-2999
KeywordsAnimals, Anti-Inflammatory Agents, Non-Steroidal, Behavior, Animal, Cocaine, Planarians, Sesquiterpenes, Stereotyped Behavior, Substance Withdrawal Syndrome
Abstract

We recently reported that parthenolide and related sesquiterpene lactones are able to prevent and reverse behavioral responses in planarian worms induced by acute cocaine exposure. Previous reports indicate that when planarians are chronically exposed to microM concentrations of cocaine, they display stereotypical withdrawal-like behaviors when the cocaine is removed. Here we report that parthenolide prevents this cocaine-induced expression of planarian withdrawal-like behaviors.
DOI10.1016/j.ejphar.2008.01.012
Alternate JournalEur. J. Pharmacol.
PubMed ID18275955