Planarians in pharmacology: parthenolide is a specific behavioral antagonist of cocaine in the planarian Girardia tigrina.
Submitted by Oné R Pagán on
Title | Planarians in pharmacology: parthenolide is a specific behavioral antagonist of cocaine in the planarian Girardia tigrina. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Pagán, OR, Baker, D, Deats, S, Montgomery, E, Tenaglia, M, Randolph, C, Kotturu, D, Tallarida, C, Bach, D, Wilk, G, Rawls, S, Raffa, RB |
Journal | Int J Dev Biol |
Volume | 56 |
Issue | 1-3 |
Pagination | 193-6 |
Date Published | 2012 |
ISSN | 1696-3547 |
Keywords | Animals, Anti-Inflammatory Agents, Non-Steroidal, Behavior, Animal, Cocaine, Dopamine Uptake Inhibitors, Excitatory Amino Acid Agonists, Methamphetamine, N-Methylaspartate, Nicotine, Nicotinic Agonists, Planarians, Regeneration, Seizures, Sesquiterpenes |
Abstract | Planarians are traditional animal models in developmental and regeneration biology. Recently, these organisms are arising as vertebrate-relevant animal models in neuropharmacology. Using an adaptation of published behavioral protocols, we have described the alleviation of cocaine-induced planarian seizure-like movements (pSLM) by a naturally-occurring sesquiterpene lactone, parthenolide. Interestingly, parthenolide does not prevent the expression of pSLM induced by amphetamines; in vertebrates, amphetamines interact with the same protein target as cocaine. Parthenolide is also unable to prevent pSLM elicited by the cholinergic com-pounds nicotine and cytisine or by the glutamatergic agents L- or D- glutamic acid or NMDA. Thus, we conclude that parthenolide is a specific anti-cocaine agent in this experimental organism. |
DOI | 10.1387/ijdb.113486op |
Alternate Journal | Int. J. Dev. Biol. |
PubMed ID | 22451007 |
Grant List | R01-DA15378 / DA / NIDA NIH HHS / United States R03-DA026518 / DA / NIDA NIH HHS / United States |