Preweaning cocaine exposure alters brain glucose metabolic rates following repeated amphetamine administration in the adult rat.
Submitted by Annelyn Torres-Reveron on
Title | Preweaning cocaine exposure alters brain glucose metabolic rates following repeated amphetamine administration in the adult rat. |
Publication Type | Journal Article |
Year of Publication | 2004 |
Authors | Melnick, SM, Torres-Reveron, A, Dow-Edwards, DL |
Journal | Brain Res Dev Brain Res |
Volume | 153 |
Issue | 1 |
Pagination | 127-34 |
Date Published | 2004 Oct 15 |
ISSN | 0165-3806 |
Keywords | Amphetamine, Animals, Animals, Newborn, Behavior, Animal, Brain, Central Nervous System Stimulants, Cocaine, Dopamine Uptake Inhibitors, Female, Glucose, Male, Motor Activity, Rats, Sex Factors, Time Factors |
Abstract | Developmental cocaine exposure produces long-term alterations in function of many neuronal circuits. This study examined glucose metabolic rates following repeated amphetamine administration in adult male and female rats pretreated with cocaine during postnatal days (PND) 11-20. PND11-20 cocaine increased the response to amphetamine in many components of the motor system and the dorsal caudate-putamen, in particular, and decreased the metabolic response in the hypothalamus. While amphetamine alone produced widespread increases in metabolism, there were no cocaine-related effects in the mesolimbic, limbic or sensory structures. These data suggest that a brief cocaine exposure during development can alter ontogeny and result in abnormal neuronal responses to repeated psychostimulant administration in adulthood. |
DOI | 10.1016/j.devbrainres.2004.07.010 |
Alternate Journal | Brain Res. Dev. Brain Res. |
PubMed ID | 15464226 |