Progesterone signaling mechanisms in brain and behavior.
Submitted by Mario G Oyola on
Title | Progesterone signaling mechanisms in brain and behavior. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Mani, SK, Oyola, MG |
Journal | Front Endocrinol (Lausanne) |
Volume | 3 |
Pagination | 7 |
Date Published | 2012 |
ISSN | 1664-2392 |
Abstract | Steroid hormone, progesterone, modulates neuroendocrine functions in the central nervous system resulting in alterations in physiology and behavior. These neuronal effects are mediated primarily by intracellular progestin receptors (PRs) in the steroid-sensitive neurons, resulting in transcription-dependent genomic actions (classical mechanism). In addition to progesterone, intracellular PRs can also be activated in a "ligand-independent" manner by neurotransmitters, peptide growth factors, cyclic nucleotides, and neurosteroids. Recent studies indicate that rapid, non-classical progesterone actions involving cytoplasmic kinase signaling and/or extranuclear PRs can result in both transcription-independent and transcription-dependent actions. Cross-talk between extranuclear and classical intracellular signaling pathways promotes progesterone-dependent behavior in mammals. This review focuses on the mechanisms by which progesterone-initiated signaling mechanisms converge with PRs in the brain to modulate reproductive behavior in female rodents. |
DOI | 10.3389/fendo.2012.00007 |
Alternate Journal | Front Endocrinol (Lausanne) |
PubMed ID | 22649404 |
PubMed Central ID | PMC3355960 |
Grant List | R01 HD062512 / HD / NICHD NIH HHS / United States R25 GM069234 / GM / NIGMS NIH HHS / United States |