Synthesis and characterization of novel polyanhydrides with tailored erosion mechanisms.

María del Pilar Torres-González's picture
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TitleSynthesis and characterization of novel polyanhydrides with tailored erosion mechanisms.
Publication TypeJournal Article
Year of Publication2006
AuthorsTorres, MP, Vogel, BM, Narasimhan, B, Mallapragada, SK
JournalJ Biomed Mater Res A
Date Published2006 Jan
KeywordsBiocompatible Materials, Biodegradation, Environmental, Drug Carriers, Magnetic Resonance Spectroscopy, Materials Testing, Microscopy, Electron, Scanning, Polyanhydrides, Solubility, Surface Properties, Thermodynamics

We have designed a new synthesis route to create polyanhydrides based on monomers that contain hydrophilic entities within highly hydrophobic backbones. The method results in polyanhydrides that can be easily processed into drug-containing tablets. The synthesis, characterization, and erosion studies of polyanhydride copolymers based on 1,6-bis(p-carboxyphenoxy)hexane (CPH), which is highly hydrophobic, and 1,8-bis(p-carboxyphenoxy)-3,6-dioxaoctane (CPTEG), which has hydrophilic oligomeric ethylene glycol segments in the monomer unit, was performed using a combination of molecular spectroscopy, thermal analysis, gravimetry, and scanning electron microscopy. The studies demonstrate that by increasing the CPH content in the CPTEG:CPH copolymers, the erosion of the system can be tailored from bulk-eroding to surface-eroding mechanism. These systems have promise as protein carriers.

Alternate JournalJ Biomed Mater Res A
PubMed ID16138330