The actin cytoskeleton in presynaptic assembly.
Enviado por Daniel Alfonso Colón-Ramos el
Título | The actin cytoskeleton in presynaptic assembly. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Autores | Nelson, JC, Stavoe, AKH, Colón-Ramos, DA |
Journal | Cell Adh Migr |
Volume | 7 |
Issue | 4 |
Pagination | 379-87 |
Date Published | 2013 Jul-Aug |
ISSN | 1933-6926 |
Palabras clave | Actins, Animals, Cytoskeleton, Models, Biological, Synapses, Synaptic Vesicles |
Abstract | Dramatic morphogenetic processes underpin nearly every step of nervous system development, from initial neuronal migration and axon guidance to synaptogenesis. Underlying this morphogenesis are dynamic rearrangements of cytoskeletal architecture. Here we discuss the roles of the actin cytoskeleton in the development of presynaptic terminals, from the elaboration of terminal arbors to the recruitment of presynaptic vesicles and active zone components. The studies discussed here underscore the importance of actin regulation at every step in neuronal circuit assembly. |
DOI | 10.4161/cam.24803 |
Alternate Journal | Cell Adh Migr |
PubMed ID | 23628914 |
PubMed Central ID | PMC3739815 |
Grant List | R01 NS076558 / NS / NINDS NIH HHS / United States R01 NS076558 / NS / NINDS NIH HHS / United States T32 GM007223 / GM / NIGMS NIH HHS / United States |