The actin cytoskeleton in presynaptic assembly.

Imagen de Daniel Alfonso Colón-Ramos
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TítuloThe actin cytoskeleton in presynaptic assembly.
Publication TypeJournal Article
Year of Publication2013
AutoresNelson, JC, Stavoe, AKH, Colón-Ramos, DA
JournalCell Adh Migr
Date Published2013 Jul-Aug
Palabras claveActins, Animals, Cytoskeleton, Models, Biological, Synapses, Synaptic Vesicles

Dramatic morphogenetic processes underpin nearly every step of nervous system development, from initial neuronal migration and axon guidance to synaptogenesis. Underlying this morphogenesis are dynamic rearrangements of cytoskeletal architecture. Here we discuss the roles of the actin cytoskeleton in the development of presynaptic terminals, from the elaboration of terminal arbors to the recruitment of presynaptic vesicles and active zone components. The studies discussed here underscore the importance of actin regulation at every step in neuronal circuit assembly.

Alternate JournalCell Adh Migr
PubMed ID23628914
PubMed Central IDPMC3739815
Grant ListR01 NS076558 / NS / NINDS NIH HHS / United States
R01 NS076558 / NS / NINDS NIH HHS / United States
T32 GM007223 / GM / NIGMS NIH HHS / United States