Alternative splicing in disease and therapy.

Imagen de Mariano Garcia-Blanco
TítuloAlternative splicing in disease and therapy.
Publication TypeJournal Article
Year of Publication2004
AutoresGarcía-Blanco, MA, Baraniak, AP, Lasda, EL
JournalNat Biotechnol
Volume22
Issue5
Pagination535-46
Date Published2004 May
ISSN1087-0156
Palabras claveAlternative Splicing, Base Sequence, Genetic Predisposition to Disease, Humans, Phenotype, RNA, Therapeutics
Abstract

Alternative splicing is the major source of proteome diversity in humans and thus is highly relevant to disease and therapy. For example, recent work suggests that the long-sought-after target of the analgesic acetaminophen is a neural-specific, alternatively spliced isoform of cyclooxygenase 1 (COX-1). Several important diseases, such as cystic fibrosis, have been linked with mutations or variations in either cis-acting elements or trans-acting factors that lead to aberrant splicing and abnormal protein production. Correction of erroneous splicing is thus an important goal of molecular therapies. Recent experiments have used modified oligonucleotides to inhibit cryptic exons or to activate exons weakened by mutations, suggesting that these reagents could eventually lead to effective therapies.

DOI10.1038/nbt964
Alternate JournalNat. Biotechnol.
PubMed ID15122293