Amplification of a gene related to mammalian mdr genes in drug-resistant Plasmodium falciparum.

Enviado por Adelfa Serrano-Brizuela el

Imagen de Adelfa Serrano-Brizuela
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TítuloAmplification of a gene related to mammalian mdr genes in drug-resistant Plasmodium falciparum.
Publication TypeJournal Article
Year of Publication1989
AutoresWilson, CM, Serrano, AE, Wasley, A, Bogenschutz, MP, Shankar, AH, Wirth, DF
JournalScience
Volume244
Issue4909
Pagination1184-6
Date Published1989 Jun 9
ISSN0036-8075
Palabras claveAmino Acid Sequence, Animals, ATP-Binding Cassette Transporters, Base Sequence, Drug Resistance, Gene Amplification, Invertebrate Hormones, Mice, Molecular Sequence Data, Nucleic Acid Hybridization, Plasmodium falciparum, Protozoan Proteins, Sequence Homology, Nucleic Acid
Abstract

The malaria parasite Plasmodium falciparum contains at least two genes related to the mammalian multiple drug resistance genes, and at least one of the P. falciparum genes is expressed at a higher level and is present in higher copy number in a strain that is resistant to multiple drugs than in a strain that is sensitive to the drugs.
Alternate JournalScience
PubMed ID2658061
Grant List1F23 AI07801-01 / AI / NIAID NIH HHS / United States
1K11 AI00892-01 / AI / NIAID NIH HHS / United States