Analysis of p-chlorobenzoic acid in water by liquid chromatography-tandem mass spectrometry.
Enviado por Fernando Rosario-Ortiz el
Título | Analysis of p-chlorobenzoic acid in water by liquid chromatography-tandem mass spectrometry. |
Publication Type | Journal Article |
Year of Publication | 2007 |
Autores | Vanderford, BJ, Rosario-Ortiz, FL, Snyder, SA |
Journal | J Chromatogr A |
Volume | 1164 |
Issue | 1-2 |
Pagination | 219-23 |
Date Published | 2007 Sep 14 |
ISSN | 0021-9673 |
Palabras clave | Chlorobenzoates, Chromatography, Liquid, Hydrogen Peroxide, Molecular Structure, Reproducibility of Results, Tandem Mass Spectrometry, Water, Water Pollutants, Chemical, Water Supply |
Abstract | para-Chlorobenzoic acid (p-CBA) is typically used as a probe compound to indirectly quantify hydroxyl radicals formed during advanced oxidation processes used in drinking water and wastewater treatment. A method has been developed for the sensitive analysis of p-CBA in water using liquid chromatography-tandem mass spectrometry (LC-MS/MS). A reporting limit in water of 100 ng/L was determined for the method, which is 40-fold lower than the 4.0 microg/L reporting limit of the widely used liquid chromatography with UV detection (LC-UV) method. The method was found to be robust in difficult matrices such as wastewater and highly selective, unlike LC-UV which relies on non-specific detection at 234 nm. The detection of p-CBA below 1 microg/L during bench-scale ozonation of wastewater after hydrogen peroxide addition was demonstrated. Duplicate samples were analyzed by LC-MS/MS and LC-UV and results were found to be comparable at concentrations quantifiable by both methods. |
DOI | 10.1016/j.chroma.2007.07.035 |
Alternate Journal | J Chromatogr A |
PubMed ID | 17689544 |