Anti-muscarinic activity of a family of C11N5 compounds isolated from Agelas sponges.
Enviado por Walter Silva el
Título | Anti-muscarinic activity of a family of C11N5 compounds isolated from Agelas sponges. |
Publication Type | Journal Article |
Year of Publication | 1992 |
Autores | Rosa, R, Silva, W, G de Motta, E, Rodríguez, AD, Morales, JJ, Ortiz, M |
Journal | Experientia |
Volume | 48 |
Issue | 9 |
Pagination | 885-7 |
Date Published | 1992 Sep 15 |
ISSN | 0014-4754 |
Palabras clave | Alkaloids, Animals, Binding, Competitive, Brain, Cell Membrane, In Vitro Techniques, Parasympatholytics, Porifera, Pyrroles, Radioligand Assay, Rats, Receptors, Muscarinic |
Abstract | In a search for potential target sites for C11N5 compounds obtained from marine sponges of the genus Agelas we evaluated their interaction with muscarinic acetylcholine receptors from rat brain membranes. In competition experiments with 3H-QNB these compounds displayed the following rank order of potency: sceptrin greater than oroidin greater than or equal to dibromosceptrin greater than or equal to clathrodin. Sceptrin (50 microM) was shown to be a competitive inhibitor of 3H-QNB binding as revealed by Scatchard analysis. The results demonstrate the ability of these compounds to interact with multiple target molecules in the micromolar range. |
Alternate Journal | Experientia |
PubMed ID | 1397186 |
Grant List | GM08102 / GM / NIGMS NIH HHS / United States NS27259 / NS / NINDS NIH HHS / United States RR03035 / RR / NCRR NIH HHS / United States |