The cell biology of synaptic specificity during development.

Imagen de Daniel Alfonso Colón-Ramos
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TítuloThe cell biology of synaptic specificity during development.
Publication TypeJournal Article
Year of Publication2013
AutoresChristensen, R, Shao, Z, Colón-Ramos, DA
JournalCurr Opin Neurobiol
Volume23
Issue6
Pagination1018-26
Date Published2013 Dec
ISSN1873-6882
Palabras claveAnimals, Central Nervous System, Cytoskeleton, Humans, Neurogenesis, Synapses
Abstract

Proper circuit connectivity is critical for nervous system function. Connectivity derives from the interaction of two interdependent modules: synaptic specificity and synaptic assembly. Specificity involves both targeting of neurons to specific laminar regions and the formation of synapses onto defined subcellular areas. In this review, we focus discussion on recently elucidated molecular mechanisms that control synaptic specificity and link them to synapse assembly. We use these molecular pathways to underscore fundamental cell biological concepts that underpin, and help explain, the rules governing synaptic specificity.

DOI10.1016/j.conb.2013.07.004
Alternate JournalCurr. Opin. Neurobiol.
PubMed ID23932598
PubMed Central IDPMC3886710
Grant ListR01 NS076558 / NS / NINDS NIH HHS / United States
R01 NS076558 / NS / NINDS NIH HHS / United States