CSF proteomic fingerprints for HIV-associated cognitive impairment.
Enviado por Loyda Milagros Melendez, Ph.D. el
Título | CSF proteomic fingerprints for HIV-associated cognitive impairment. |
Publication Type | Journal Article |
Year of Publication | 2007 |
Autores | Laspiur, JPérez, Anderson, ER, Ciborowski, P, Wojna, V, Rozek, W, Duan, F, Mayo, R, Rodríguez, E, Plaud-Valentin, M, Rodríguez-Orengo, J, Gendelman, HE, Melendez, LM |
Journal | J Neuroimmunol |
Volume | 192 |
Issue | 1-2 |
Pagination | 157-70 |
Date Published | 2007 Dec |
ISSN | 0165-5728 |
Palabras clave | Adult, Cerebrospinal Fluid, Cognition Disorders, Cohort Studies, Electrophoresis, Gel, Two-Dimensional, Female, HIV Infections, Humans, Male, Mass Spectrometry, Middle Aged, Molecular Sequence Data, Neuropsychological Tests, Proteomics, Viral Load |
Abstract | Cognitive impairment remains a major complication of advanced human immunodeficiency virus (HIV) infection despite the widespread use of anti-retroviral therapy. Diagnosis is made by exclusion making biomarkers of great potential use. Thus, we used an integrated proteomics platform to assess cerebrospinal fluid protein profiles from 50 HIV-1 seropositive Hispanic women. Nine of 38 proteins identified were unique in those patients with cognitive impairment (CI). These proteins were linked to cell signaling, structural function, and antioxidant activities. This work highlights, in a preliminary manner, the utility of proteomic profiling for biomarker discovery for HIV-1 associated cognitive dysfunction. |
DOI | 10.1016/j.jneuroim.2007.08.004 |
Alternate Journal | J. Neuroimmunol. |
PubMed ID | 17950469 |
PubMed Central ID | PMC2248223 |
Grant List | G12 RR003051-22 / RR / NCRR NIH HHS / United States NCRR-RCMI G12 RR-03051 / / PHS HHS / United States NINDS U54 NS4301 / NS / NINDS NIH HHS / United States P20 RR011126 / RR / NCRR NIH HHS / United States P20 RR011126-110019 / RR / NCRR NIH HHS / United States P20 RR011126-110020 / RR / NCRR NIH HHS / United States R01 NS034239 / NS / NINDS NIH HHS / United States R01 NS034239-12 / NS / NINDS NIH HHS / United States R01 NS34239 / NS / NINDS NIH HHS / United States R37 NS36136 / NS / NINDS NIH HHS / United States RCMI-CRC-1P20RR11126 / RR / NCRR NIH HHS / United States U54 NS043011 / NS / NINDS NIH HHS / United States U54 NS043011-06 / NS / NINDS NIH HHS / United States |