Different levels of HIV DNA copy numbers in cerebrospinal fluid cellular subsets.
Enviado por Loyda Milagros Melendez, Ph.D. el
Título | Different levels of HIV DNA copy numbers in cerebrospinal fluid cellular subsets. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Autores | Agsalda-Garcia, M, Shiramizu, B, Melendez, L, Plaud, M, Liang, C-Y, Wojna, V |
Journal | J Health Care Poor Underserved |
Volume | 24 |
Issue | 4 Suppl |
Pagination | 8-16 |
Date Published | 2013 Nov |
ISSN | 1548-6869 |
Palabras clave | Adult, Antigens, CD14, Cognition Disorders, Cohort Studies, DNA, Viral, Female, Hawaii, HIV Infections, Humans, Lymphocytes, Male, Middle Aged, Monocytes, Puerto Rico, Sampling Studies |
Abstract | Inequities in the incidence of HIV infection and AIDS with continued persistence of HIV-associated neurocognitive disorders (HAND) exist in populations in Hawaii (HI) and Puerto Rico (PR). We previously reported that peripheral monocyte HIV DNA levels are high in patients in Hawaii with HAND and we now hypothesize that similar findings would be observed in the cerebrospinal fluid (CSF) cellular subsets. Cerebrospinal fluid cells were obtained from patients from PR and HI undergoing neurocognitive testing and sorted into monocytes (CD14+) and lymphocytes (CD14-) and HIV DNA was measured. From six PR subjects (three HAND, three normal cognition, NC) and six HI subjects (three HAND, three NC), HIV DNA burden in CD14+ cells was higher in HAND than NC patients; NC patients had higher HIV DNA burden in CD14-cells versus HAND. Differences in HIV DNA burden in particular CSF cellular subsets suggest that HIV DNA burden may play a role in HAND neuropathogenesis. |
DOI | 10.1353/hpu.2014.0010 |
Alternate Journal | J Health Care Poor Underserved |
PubMed ID | 24241256 |
PubMed Central ID | PMC3844931 |
Grant List | F31 AI081450 / AI / NIAID NIH HHS / United States F31AI081450 / AI / NIAID NIH HHS / United States MD007584 / MD / NIMHD NIH HHS / United States NS053345 / NS / NINDS NIH HHS / United States P20 GM103516 / GM / NIGMS NIH HHS / United States P20 RR011126 / RR / NCRR NIH HHS / United States P20GM103516 / GM / NIGMS NIH HHS / United States P20RR11126 / RR / NCRR NIH HHS / United States R01 MH083516 / MH / NIMH NIH HHS / United States R01 NS053345 / NS / NINDS NIH HHS / United States R01MH083516 / MH / NIMH NIH HHS / United States R21 MH095524 / MH / NIMH NIH HHS / United States R21MH095524 / MH / NIMH NIH HHS / United States R25 MH080661 / MH / NIMH NIH HHS / United States R25MH080661 / MH / NIMH NIH HHS / United States S11 NS046278 / NS / NINDS NIH HHS / United States S11NS046278 / NS / NINDS NIH HHS / United States U54 MD007584 / MD / NIMHD NIH HHS / United States U54 MD007587 / MD / NIMHD NIH HHS / United States U54 NS043011 / NS / NINDS NIH HHS / United States U54 RR026136 / RR / NCRR NIH HHS / United States U54MD007587 / MD / NIMHD NIH HHS / United States U54NS43011 / NS / NINDS NIH HHS / United States |