Double-blind pilot study of mesalamine vs. placebo for treatment of chronic diarrhea and nonspecific colitis in immunocompetent HIV patients.
Enviado por Jose F Rodriguez-Orengo el
Título | Double-blind pilot study of mesalamine vs. placebo for treatment of chronic diarrhea and nonspecific colitis in immunocompetent HIV patients. |
Publication Type | Journal Article |
Year of Publication | 2006 |
Autores | Rodríguez-Torres, M, Rodríguez-Orengo, JF, Ríos-Bedoya, CF, Fernández-Carbia, A, Salgado-Mercado, R, Marxuach-Cuétara, AM |
Journal | Dig Dis Sci |
Volume | 51 |
Issue | 1 |
Pagination | 161-7 |
Date Published | 2006 Jan |
ISSN | 0163-2116 |
Palabras clave | Adult, Anti-Inflammatory Agents, Non-Steroidal, Biopsy, Chronic Disease, Colitis, Colonoscopy, Diarrhea, Double-Blind Method, Female, Follow-Up Studies, HIV, HIV Antibodies, HIV Infections, Humans, Immunocompromised Host, Male, Mesalamine, Pilot Projects, Prospective Studies, Severity of Illness Index, Treatment Outcome |
Abstract | Chronic diarrhea and colitis are common in patients positive for human immunodeficiency virus (HIV) under highly active antiretroviral treatment (HAART). This prospective double-blind study explores the effect of mesalamine vs. placebo in HIV-positive patients. Thirteen HIV-infected patients with noninfectious chronic diarrhea and > 250 CD4+ cells/mm(3) were randomized to mesalamine (2.4 g/day; n = 9) or placebo (n = 4) for 6 weeks. Colonoscopy was performed at baseline and week 6, and biopsies were obtained to calculate the Biopsy Activity Index (BAI). Diarrhea was assessed at baseline and end of treatment using the Disease Activity Index (DAI). Patients and clinicians completed Patient Global Improvement index (PGI) and Clinical Global Improvement index (CGI) at weeks 2 and 6. Comparisons at week 6 were statistically significant between mesalamine and placebo groups for BAI (P = 0.03), DAI (P = 0.007), PGI (P = 0.008), and CGI (P = 0.008). Furthermore, major improvements were documented in the mesalamine group at week 6 compared to baseline for all variables, whereas the placebo group did not have any. Mesalamine was effective for treatment of chronic diarrhea and moderate nonspecific colitis in HIV patients. |
DOI | 10.1007/s10620-006-3102-6 |
Alternate Journal | Dig. Dis. Sci. |
PubMed ID | 16416230 |
Grant List | 1P20RR11126 / RR / NCRR NIH HHS / United States 2G12RR03050-19 / RR / NCRR NIH HHS / United States G1212RR03051 / RR / NCRR NIH HHS / United States R01 AI14941 / AI / NIAID NIH HHS / United States |