Fear conditioning enhances different temporal components of tone-evoked spike trains in auditory cortex and lateral amygdala.

Imagen de Gregory Quirk
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TítuloFear conditioning enhances different temporal components of tone-evoked spike trains in auditory cortex and lateral amygdala.
Publication TypeJournal Article
Year of Publication1997
AutoresQuirk, GJ, Armony, JL, LeDoux, JE
JournalNeuron
Volume19
Issue3
Pagination613-24
Date Published1997 Sep
ISSN0896-6273
Palabras claveAcoustic Stimulation, Action Potentials, Amygdala, Animals, Association Learning, Auditory Cortex, Conditioning, Classical, Extinction, Psychological, Fear, Male, Memory, Neural Pathways, Neurons, Rats, Rats, Sprague-Dawley, Reaction Time, Time Factors
Abstract

Single neurons were recorded in freely behaving rats during fear conditioning from areas of auditory cortex that project to the lateral nucleus of the amygdala (LA). The latency and rate of conditioning and extinction were analyzed, and the results were compared to previous recordings from LA itself. Auditory cortex neurons took more trials to learn, and they responded more slowly than LA neurons within trials. Short-latency plasticity in LA, therefore, reflects inputs from the auditory thalamus rather than the auditory cortex. Unlike LA cells, some auditory cortex cells showed late conditioned responses that seemed to anticipate the unconditioned stimulus, while others showed extinction-resistant memory storage. Thus, rapid conditioning of fear responses to potentially dangerous stimuli depends on plasticity in the amygdala, while cortical areas may be particularly involved in higher cognitive (mnemonic and attentional) processing of fear experiences.

Alternate JournalNeuron
PubMed ID9331352
Grant ListMH00956 / MH / NIMH NIH HHS / United States
MH38774 / MH / NIMH NIH HHS / United States
MH46516 / MH / NIMH NIH HHS / United States