Genome-wide approaches for cancer gene discovery.

Imagen de Paul Lizardi
PDF versionPDF version
TítuloGenome-wide approaches for cancer gene discovery.
Publication TypeJournal Article
Year of Publication2011
AutoresLizardi, PM, Forloni, M, Wajapeyee, N
JournalTrends Biotechnol
Volume29
Issue11
Pagination558-68
Date Published2011 Nov
ISSN1879-3096
Palabras claveAnimals, Databases, Genetic, Gene Expression Profiling, Genes, Neoplasm, Genome, Genomics, High-Throughput Screening Assays, Humans, Neoplasms, RNA Interference
Abstract

One of the central aims of cancer research is to identify and characterize cancer-causing alterations in cancer genomes. In recent years, unprecedented advances in genome-wide sequencing, functional genomics technologies for RNA interference screens and methods for evaluating three-dimensional chromatin organization in vivo have resulted in important discoveries regarding human cancer. The cancer-causing genes identified from these new genome-wide technologies have also provided opportunities for effective and personalized cancer therapy. In this review, we describe some of the most recent technologies for cancer gene discovery. We also provide specific examples in which these technologies have proven remarkably successful in uncovering important cancer-causing alterations.

DOI10.1016/j.tibtech.2011.06.003
Alternate JournalTrends Biotechnol.
PubMed ID21757246
PubMed Central IDPMC3195896
Grant List1 R21 CA116079-01 / CA / NCI NIH HHS / United States
5 R01GM080242-03 / GM / NIGMS NIH HHS / United States
P30 DK034989 / DK / NIDDK NIH HHS / United States
P30-34989 / / PHS HHS / United States
R01 GM080242-03 / GM / NIGMS NIH HHS / United States
R21 CA116079-01 / CA / NCI NIH HHS / United States