Intensification and stimulation therapy for human immunodeficiency virus type 1 reservoirs in infected persons receiving virally suppressive highly active antiretroviral therapy.
Enviado por Miguel Otero el
Título | Intensification and stimulation therapy for human immunodeficiency virus type 1 reservoirs in infected persons receiving virally suppressive highly active antiretroviral therapy. |
Publication Type | Journal Article |
Year of Publication | 2002 |
Autores | Kulkosky, J, Nunnari, G, Otero, M, Calarota, S, Dornadula, G, Zhang, H, Malin, A, Sullivan, J, Xu, Y, DeSimone, J, Babinchak, T, Stern, J, Cavert, W, Haase, A, Pomerantz, RJ |
Journal | J Infect Dis |
Volume | 186 |
Issue | 10 |
Pagination | 1403-11 |
Date Published | 2002 Nov 15 |
ISSN | 0022-1899 |
Palabras clave | Adult, Anti-HIV Agents, Antiretroviral Therapy, Highly Active, HIV Infections, HIV-1, Humans, Immunity, Male |
Abstract | Highly active antiretroviral therapy (HAART) has led to significant changes in mortality and morbidity in the human immunodeficiency virus type 1 (HIV-1) epidemic. Nevertheless, because of molecular mechanisms of viral persistence, HAART does not eradicate HIV-1. Didanosine and hydroxyurea were added to the antiretroviral regimens of 3 HIV-1-infected men who were receiving stable HAART and who had HIV-1 RNA levels <50 copies/mL at the initiation of the study protocol, as a novel intensification to attack cryptic viral replication; low-dose OKT3 was then administered, followed by a course of interleukin-2, to stimulate latent provirus. Replication-competent virus was undetectable after treatment, and plasma viral RNA was either undetectable or <5 copies/mL. In trial periods during which no antiretroviral therapy was administered, the patients developed plasma viral rebound. This translational approach combines novel intensification and stimulation therapy to deplete residual HIV-1 reservoirs. Additional experimental approaches must be developed if HIV-1 eradication is to become possible in patients receiving virally suppressive HAART. |
DOI | 10.1086/344357 |
Alternate Journal | J. Infect. Dis. |
PubMed ID | 12404155 |
Grant List | AI-46289 / AI / NIAID NIH HHS / United States |