Local regulation of L-type Ca²⁺ channel sparklets in arterial smooth muscle.
Enviado por Manuel F Navedo el
Título | Local regulation of L-type Ca²⁺ channel sparklets in arterial smooth muscle. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Autores | Navedo, MF, Amberg, GC |
Journal | Microcirculation |
Volume | 20 |
Issue | 4 |
Pagination | 290-8 |
Date Published | 2013 May |
ISSN | 1549-8719 |
Palabras clave | A Kinase Anchor Proteins, Animals, Arteries, Calcium, Calcium Channels, L-Type, Humans, Ion Channel Gating, Muscle Proteins, Muscle, Smooth, Vascular, Sarcolemma |
Abstract | This review addresses the latest advances in our understanding of the regulation of a novel Ca²⁺ signal called L-type Ca²⁺ channel sparklets in arterial smooth muscle. L-type Ca²⁺ channel sparklets are elementary Ca²⁺ influx events produced by the opening of a single or a small cluster of L-type Ca²⁺ channels. These Ca²⁺ signals were first visualized in the vasculature in arterial smooth muscle cells. In these cells, L-type Ca²⁺ channel sparklets display two functionally distinct gating modalities that regulate local and global [Ca²⁺](i). The activity of L-type Ca²⁺ channel sparklets varies regionally within a cell depending on the dynamic activity of a cohort of protein kinases and phosphatases recruited to L-type Ca²⁺ channels in the arterial smooth muscle sarcolemma in a complex coordinated by the scaffolding molecule AKAP150. We also described a mechanism whereby clusters of L-type Ca²⁺ channels gate cooperatively to amplify intracellular Ca²⁺ signals with likely pathological consequences. |
DOI | 10.1111/micc.12021 |
Alternate Journal | Microcirculation |
PubMed ID | 23116449 |
PubMed Central ID | PMC3577995 |
Grant List | 1R01HL098200 / HL / NHLBI NIH HHS / United States R01 HL098200 / HL / NHLBI NIH HHS / United States T32 HL007828 / HL / NHLBI NIH HHS / United States |