Mammalian fatty acid synthase: closure on a textbook mechanism?

Enviado por Abel Baerga-Ortiz el

Imagen de Abel Baerga-Ortiz
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TítuloMammalian fatty acid synthase: closure on a textbook mechanism?
Publication TypeJournal Article
Year of Publication2003
AutoresLeadlay, P, Baerga-Ortiz, A
JournalChem Biol
Volume10
Issue2
Pagination101-3
Date Published2003 Feb
ISSN1074-5521
Palabras claveAnimals, Fatty Acid Synthases, Genetic Complementation Test, Humans, Insects, Models, Molecular, Protein Conformation, Recombinant Proteins
Abstract

Mammalian fatty acid synthase is a classic example of a chain-building multienzyme. A cornerstone of its mechanism has been the obligatory collaboration of two identical subunits, with fatty acyl intermediates transferring between them. Now, fresh evidence has upset this view.
Alternate JournalChem. Biol.
PubMed ID12618179