Messenger RNA reprogramming by spliceosome-mediated RNA trans-splicing.

Imagen de Mariano Garcia-Blanco
TítuloMessenger RNA reprogramming by spliceosome-mediated RNA trans-splicing.
Publication TypeJournal Article
Year of Publication2003
AutoresGarcía-Blanco, MA
JournalJ Clin Invest
Volume112
Issue4
Pagination474-80
Date Published2003 Aug
ISSN0021-9738
Palabras claveAlternative Splicing, Animals, Base Sequence, Exons, Humans, Models, Genetic, Molecular Sequence Data, Mutation, RNA Splicing, RNA, Messenger, Spliceosomes
Abstract

In the human genome, the majority of protein-encoding genes are interrupted by introns, which are removed from primary transcripts by a macromolecular enzyme known as the spliceosome. Spliceosomes can constitutively remove all the introns in a primary transcript to yield a fully spliced mRNA or alternatively splice primary transcripts leading to the production of many different mRNAs from one gene. This review examines how spliceosomes can recombine two primary transcripts in trans to reprogram messenger RNAs.

DOI10.1172/JCI19462
Alternate JournalJ. Clin. Invest.
PubMed ID12925685