Mucin-based targeted pancreatic cancer therapy.
Enviado por María del Pilar Torres-González el
Título | Mucin-based targeted pancreatic cancer therapy. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Autores | Torres, MP, Chakraborty, S, Souchek, J, Batra, SK |
Journal | Curr Pharm Des |
Volume | 18 |
Issue | 17 |
Pagination | 2472-81 |
Date Published | 2012 |
ISSN | 1873-4286 |
Palabras clave | Animals, Antineoplastic Agents, Cancer Vaccines, Drug Resistance, Neoplasm, Genetic Therapy, Humans, Immunotherapy, Molecular Targeted Therapy, Mucins, Neoplasm Proteins, Pancreatic Neoplasms |
Abstract | The prognosis of pancreatic cancer (PC) patients is very poor with a five-year survival of less than 5%. One of the major challenges in developing new therapies for PC is the lack of expression of specific markers by pancreatic tumor cells. Mucins are heavily Oglycosylated proteins characterized by the presence of short stretches of amino acid sequences repeated several times in tandem. The expression of several mucins including MUC1, MUC4, MUC5AC, and MUC16 is strongly upregulated in PC. Recent studies have also demonstrated a link between the aberrant expression and differential overexpression of mucin glycoproteins to the initiation, progression, and poor prognosis of the disease. These studies have led to increasing recognition of mucins as potential diagnostic markers and therapeutic targets in PC. In this focused review we present an overview of the therapies targeting mucins in PC, including immunotherapy (i.e. vaccines, antibodies, and radioimmunoconjugates), gene therapy, and other novel therapeutic strategies. |
Alternate Journal | Curr. Pharm. Des. |
PubMed ID | 22372499 |
PubMed Central ID | PMC3530894 |
Grant List | P50 CA127297 / CA / NCI NIH HHS / United States P50 CA127297 / CA / NCI NIH HHS / United States R01 CA078590 / CA / NCI NIH HHS / United States R01 CA131944 / CA / NCI NIH HHS / United States R01 CA131944 / CA / NCI NIH HHS / United States R01 CA133774 / CA / NCI NIH HHS / United States R01 CA133774 / CA / NCI NIH HHS / United States R01 CA78590 / CA / NCI NIH HHS / United States T32CA009479 / CA / NCI NIH HHS / United States UO1 CA111294 / CA / NCI NIH HHS / United States |