Pharmacological actions of substance P in the rat vas deferens.

Enviado por Walter Silva el

Imagen de Walter Silva
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TítuloPharmacological actions of substance P in the rat vas deferens.
Publication TypeJournal Article
Year of Publication1991
AutoresMiranda, HF, Silva, WI, Wolstenholme, WW, Cuevas, N, Ucros, A, Bustamante, D, Fernández, EH
JournalNeuropeptides
Volume18
Issue4
Pagination209-13
Date Published1991 Apr
ISSN0143-4179
Palabras claveAnimals, Dose-Response Relationship, Drug, Electric Stimulation, Male, Muscle Contraction, Muscle, Smooth, Neurons, Rats, Rats, Inbred Strains, Receptors, Neurokinin-1, Receptors, Neurotransmitter, Substance P, Synapses, Synaptic Transmission, Vas Deferens
Abstract

SP produces two different muscular responses in the isolated vas deferens of the rat. 1) A myotropic, post-synaptic effect that results from stimulation of one subtype of SP receptor, located on the membrane of the smooth muscle (NK-3 receptor). 2) A neurogenic effect at the pre-synaptic level that results from stimulation of another subtype of SP receptor, located on the nerve terminals (NK-1 receptor).
Alternate JournalNeuropeptides
PubMed ID1711166
Grant List1-G-12-RR03035-01A / RR / NCRR NIH HHS / United States