Plasma glutathione concentrations in non-infected infants born from HIV-infected mothers: developmental profile.

Imagen de Jose F Rodriguez-Orengo
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TítuloPlasma glutathione concentrations in non-infected infants born from HIV-infected mothers: developmental profile.
Publication TypeJournal Article
Year of Publication1999
AutoresChantry, CJ, Rodriguez, JL, Febo, I, Díaz, C, Rodriguez-Orengo, JF
JournalP R Health Sci J
Volume18
Issue3
Pagination267-72
Date Published1999 Sep
ISSN0738-0658
Palabras claveAdult, Age Factors, Child, Child, Preschool, Data Interpretation, Statistical, Female, Glutathione, HIV Infections, Humans, Infant, Infant, Newborn, Male, Maternal Age, Pregnancy, Pregnancy Complications, Infectious
Abstract

Glutathione (GSH) is the primary antioxidant in humans. Oxidative cellular injury is postulated to be centrally involved in diverse processes including aging, cancer, cardiovascular disease, and Human Immunodeficiency Virus (HIV) disease progression. Normal plasma GSH concentrations have been well characterized in healthy children and adults, but not during infant development. The objectives of this study were to: a) measure plasma GSH concentrations in non-infected infants born from HIV-infected mothers, to b) assess the developmental variations with age and gender, and c) evaluate for possible associations with growth, anemia, and other maternal and infant variables. One hundred and seventy (170) plasma samples from 44 HIV-uninfected infants (birth to 18 mos.) born to HIV-infected mothers from the Women and Infant Transmission Study (Puerto Rico site) were analyzed. The total plasma GSH geometric mean concentration for all samples analyzed was 1.94 (1.06) mumoles/L. A developmental effect of age was seen with lower concentrations in younger infants (0-2 months) than in older infants 4-18 months. There was no significant effect of gender, anemia, zidovudine exposure, maternal age, maternal CD4 cell percent, or infant growth, although a trend towards increasing GSH concentration was seen with increasing weight for height z-score. These findings have multiple clinical ramifications including prediction of capacity to detoxify oxidants at different ages, and partial explanation for the increased viral loads seen in HIV-infected infants.

Alternate JournalP R Health Sci J
PubMed ID10547871
Grant List1P20RR11126 / RR / NCRR NIH HHS / United States
2U01A132906 / / PHS HHS / United States
RR03051 / RR / NCRR NIH HHS / United States