Prevalence of Drug Resistance and Associated Mutations in a Population of HIV-1(+) Puerto Ricans: 2006-2010.
Enviado por Luz Milbeth Cumba Garcia el
Título | Prevalence of Drug Resistance and Associated Mutations in a Population of HIV-1(+) Puerto Ricans: 2006-2010. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Autores | Sepúlveda-Torres, LDel C, De La Rosa, A, Cumba, L, Boukli, N, Ríos-Olivares, E, Cubano, LA |
Journal | AIDS Res Treat |
Volume | 2012 |
Pagination | 934041 |
Date Published | 2012 |
ISSN | 2090-1259 |
Abstract | This is a continuation of our efforts to maintain a record of the evolution of HIV-1 infection in Puerto Rico by monitoring the expression levels of antiretroviral drug-resistance-associated mutations. Samples from 2,500 patients from 2006-2010 were analyzed using the TruGene HIV-1 genotyping kit and the OpenGene DNA sequencing system. Results show that 58.8% of males and 65.3% of females had HIV-1 with resistance to at least one medication. The average number of HIV mutations was 6.0 in males and 6.1 in females. Statistically significant differences between men and women were recorded in the levels of HIV-1 expressed mutations and antiretroviral drug resistance. The most prevalent antiretroviral medication resistance shifted from zalcitabine to nevirapine and efavirenz in the five-year period. M184V and L63P were the dominant mutations for the reverse transcriptase and the protease genes, respectively, but an increase in the incidence of minority mutations was observed. |
DOI | 10.1155/2012/934041 |
Alternate Journal | AIDS Res Treat |
PubMed ID | 22593823 |
PubMed Central ID | PMC3347695 |
Grant List | G12 MD007583 / MD / NIMHD NIH HHS / United States |
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Second Publication
Enviado por Luz Milbeth Cumba Garcia el
Second Publication