Selective antagonism by pirenzepine and N-methyl-scopolamine on muscarinic receptor subtypes of the rat vas deferens.

Enviado por Walter Silva el

Imagen de Walter Silva
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TítuloSelective antagonism by pirenzepine and N-methyl-scopolamine on muscarinic receptor subtypes of the rat vas deferens.
Publication TypeJournal Article
Year of Publication1988
AutoresMiranda, HF, Silva, WI, Wolstenholme, WW, Cuevas, N
JournalGen Pharmacol
Volume19
Issue3
Pagination417-20
Date Published1988
ISSN0306-3623
Palabras claveAnimals, Male, Muscle Contraction, Muscle, Smooth, N-Methylscopolamine, Parasympatholytics, Pirenzepine, Rats, Rats, Inbred Strains, Receptors, Muscarinic, Scopolamine Derivatives, Vas Deferens
Abstract

1. The effects of pirenzepine and N-methyl-scopolamine on the responses to ACh in the isolated rat vas deferens were studied. 2. Pirenzepine was inactive at the M2-ACh receptor. 3. N-methyl-scopolamine was a competitive antagonist (pA2 = 8.76) at M2-ACh receptor, alone or in the presence of pirenzepine. 4. Pirenzepine and N-methyl-scopolamine were both non-competitive antagonists at M1-ACh receptor. 5. The mixture of pirenzepine and N-methyl-scopolamine did not alter the type of antagonism demonstrated by each drug at the M1-ACh receptor.
Alternate JournalGen. Pharmacol.
PubMed ID3417103
Grant List2-SO6-RR-08159-07-A1 / RR / NCRR NIH HHS / United States