Shedding UV light on alternative splicing.

Enviado por Mariano Garcia-Blanco el

Imagen de Mariano Garcia-Blanco
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TítuloShedding UV light on alternative splicing.
Publication TypeJournal Article
Year of Publication2009
AutoresMarengo, MS, García-Blanco, MA
JournalCell
Volume137
Issue4
Pagination600-2
Date Published2009 May 15
ISSN1097-4172
Palabras claveAlternative Splicing, Apoptosis, DNA Damage, Humans, Phosphorylation, RNA Polymerase II, Transcription, Genetic, Ultraviolet Rays
Abstract

After DNA damage, cells modulate pre-messenger RNA (pre-mRNA) splicing to induce an anti- or proapoptotic response. In this issue, Muñoz et al. (2009) uncover a cotranscriptional mechanism for activating alternative pre-mRNA splicing after ultraviolet irradiation that depends unexpectedly on hyperphosphorylation of the RNA polymerase II C-terminal domain and decreased rates of transcription elongation.
DOI10.1016/j.cell.2009.04.054
Alternate JournalCell
PubMed ID19450507