Shedding UV light on alternative splicing.
Enviado por Mariano Garcia-Blanco el
Título | Shedding UV light on alternative splicing. |
Publication Type | Journal Article |
Year of Publication | 2009 |
Autores | Marengo, MS, García-Blanco, MA |
Journal | Cell |
Volume | 137 |
Issue | 4 |
Pagination | 600-2 |
Date Published | 2009 May 15 |
ISSN | 1097-4172 |
Palabras clave | Alternative Splicing, Apoptosis, DNA Damage, Humans, Phosphorylation, RNA Polymerase II, Transcription, Genetic, Ultraviolet Rays |
Abstract | After DNA damage, cells modulate pre-messenger RNA (pre-mRNA) splicing to induce an anti- or proapoptotic response. In this issue, Muñoz et al. (2009) uncover a cotranscriptional mechanism for activating alternative pre-mRNA splicing after ultraviolet irradiation that depends unexpectedly on hyperphosphorylation of the RNA polymerase II C-terminal domain and decreased rates of transcription elongation. |
DOI | 10.1016/j.cell.2009.04.054 |
Alternate Journal | Cell |
PubMed ID | 19450507 |