Structured treatment interruptions to control HIV-1 and limit drug exposure.

Enviado por Luis Montaner el

Imagen de Luis Montaner
PDF versionPDF version
TítuloStructured treatment interruptions to control HIV-1 and limit drug exposure.
Publication TypeJournal Article
Year of Publication2001
AutoresMontaner, LJ
JournalTrends Immunol
Volume22
Issue2
Pagination92-6
Date Published2001 Feb
ISSN1471-4906
Palabras claveAcquired Immunodeficiency Syndrome, Acute Disease, Anti-HIV Agents, Chronic Disease, Drug Administration Schedule, HIV-1, Humans, Immunosuppressive Agents, Risk Factors
Abstract

Although therapy-mediated suppression of HIV-1 is effective and results in a degree of immune reconstitution, the complications resulting from life-long treatment emphasize the need for alternatives. This review discusses the use of structured interruptions in antiviral therapy to induce drug-free periods of immune-mediated control of HIV-1. Such an approach has the ultimate objective of harnessing anti-viral immune responses, reducing drug exposure (toxicity and cost) and potentially extending the clinical benefits of a suppressive treatment regimen.
Alternate JournalTrends Immunol.
PubMed ID11286710