Synapse location during growth depends on glia location.
Enviado por Daniel Alfonso Colón-Ramos el
Título | Synapse location during growth depends on glia location. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Autores | Shao, Z, Watanabe, S, Christensen, R, Jorgensen, EM, Colón-Ramos, DA |
Journal | Cell |
Volume | 154 |
Issue | 2 |
Pagination | 337-50 |
Date Published | 2013 Jul 18 |
ISSN | 1097-4172 |
Palabras clave | Animals, Body Size, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Embryonic Development, Epidermis, Mutation, Neurites, Neuroglia, Receptors, Fibroblast Growth Factor, Sodium-Phosphate Cotransporter Proteins, Type I, Synapses |
Abstract | Synaptic contacts are largely established during embryogenesis and are then maintained during growth. To identify molecules involved in this process, we conducted a forward genetic screen in C. elegans and identified cima-1. In cima-1 mutants, synaptic contacts are correctly established during embryogenesis, but ectopic synapses emerge during postdevelopmental growth. cima-1 encodes a solute carrier in the SLC17 family of transporters that includes sialin, a protein that when mutated in humans results in neurological disorders. cima-1 does not function in neurons but rather functions in the nearby epidermal cells to correctly position glia during postlarval growth. Our findings indicate that CIMA-1 antagonizes the FGF receptor (FGFR), and does so most likely by inhibiting FGFR's role in epidermal-glia adhesion rather than signaling. Our data suggest that epidermal-glia crosstalk, in this case mediated by a transporter and the FGF receptor, is vital to preserve embryonically derived circuit architecture during postdevelopmental growth. |
DOI | 10.1016/j.cell.2013.06.028 |
Alternate Journal | Cell |
PubMed ID | 23870123 |
PubMed Central ID | PMC3808971 |
Grant List | R00 NS057931 / NS / NINDS NIH HHS / United States R01 NS034307 / NS / NINDS NIH HHS / United States R01 NS034307 / NS / NINDS NIH HHS / United States R01 NS076558 / NS / NINDS NIH HHS / United States R01 NS076558 / NS / NINDS NIH HHS / United States / / Howard Hughes Medical Institute / United States |