The Xenopus ortholog of the nuclear hormone receptor Nr2e3 is primarily expressed in developing photoreceptors.

Enviado por Reyna I. Martínez De Luna el

Imagen de Reyna I. Martínez De Luna
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TítuloThe Xenopus ortholog of the nuclear hormone receptor Nr2e3 is primarily expressed in developing photoreceptors.
Publication TypeJournal Article
Year of Publication2007
AutoresDe Luna, RIMartinez, El-Hodiri, HM
JournalInt J Dev Biol
Volume51
Issue3
Pagination235-40
Date Published2007
ISSN0214-6282
Palabras claveAmino Acid Sequence, Animals, Cluster Analysis, Embryo, Nonmammalian, Gene Expression Regulation, Developmental, In Situ Hybridization, Molecular Sequence Data, Notochord, Orphan Nuclear Receptors, Phylogeny, Pineal Gland, Protein Structure, Tertiary, Receptors, Cytoplasmic and Nuclear, Retina, Retinal Rod Photoreceptor Cells, Sequence Homology, Amino Acid, Transcription Factors, Xenopus, Xenopus Proteins
Abstract

Nr2e3 is a nuclear hormone receptor that is involved in rod photoreceptor differentiation. The Nr2e3 gene was previously identified in humans, mice, zebrafish and chicken. In all species, Nr2e3 expression is restricted to the retina and is believed to have a role in rod photoreceptor specification and maintenance. Here we report the identification and characterization of the Xenopus Nr2e3. We found that Nr2e3 is primarily expressed in developing rod photoreceptors. In contrast to other species, Nr2e3 is also expressed in the notochord and pineal gland during Xenopus laevis development.
DOI10.1387/ijdb.062236rm
Alternate JournalInt. J. Dev. Biol.
PubMed ID17486544
Grant ListEY015480 / EY / NEI NIH HHS / United States