Genomas®, Inc. is a biomedical company advancing DNA-guided medicine and personalized health. The company develops revolutionary PhyzioType™ systems for DNA-guided diagnosis and prevention of metabolic disorders induced by drugs in cardiovascular and psychiatric medicine. PhyzioTypeTM systems provide physicians with the unprecedented capability to select for each patient the safest drug treatment. Genomas is located in Hartford, CT on the campus of Hartford Hospital. For more information please access
www.genomas.net
Publications:
1. Liu J, Pearlson G, Windemuth A, Ruaño G, Perrone-Bizzozero NI, Calhoun V. Combining fMRI and SNP Data to Investigate Connections Between Brain Function and Genetics Using Parallel ICA. Human Brain Mapping, In Press, 2007
2. de Leon J, Correa JC, Ruaño G, Windemuth A, Arranz MJ, Diaz FJ. Exploring genetic variations that may be associated with the direct effects of some antipsychotics on lipid levels. Schizophrenia Research, 98: 40-46, 2008
3. Ruaño G, Thompson PD, Windemuth A, Seip RL, Dande A, Sarokin A, Kocherla M, Smith A, Holford TR, Wu AH. Physiogenomic Association of Statin-Related Myalgia to Serotonin Receptors. Muscle & Nerve, 36: 329-335, 2007
4. Ruaño G, Blair CL, Bower B, Windemuth A, Kocherla M, Aleman Y, Pearlson G, Goethe JW, Schwartz HI. Somatic Complications of Psychotropic Medications in a Patient with Multiple CYP2 Drug Metabolism Deficiencies. Connecticut Medicine, 71: 197-200, 2007
5. de Leon J, Susce MT, Johnson M, Hardin M, Pointer L, Ruaño G, Windemuth A, Diaz FJ. A clinical study of the association of antipsychotics with hyperlipidemia. Schizophrenia Research, 92: 95-102, 2007
6. Ruaño G, Goethe JW, Caley C, Woolley S, Holford TR, Kocherla M, Windemuth A, de Leon J. Physiogenomic Comparison of Weight Profiles of Olanzapine- and Risperidone-Treated Patients. Molecular Psychiatry, 12: 474- 482, 2007
7. Ruaño G, Windemuth A, Kocherla M, Holford TR, Fernandez ML, Forsythe CE, Wood RJ, Kraemer WJ, Volek JS. Physiogenomic analysis of weight loss induced by dietary carbohydrate restriction. Nutrition and Metabolism, 3: 20-30, 2006
8. Ruaño G, Makowski G, Windemuth A, Kocherla M, Weiss S, Goethe JW, Bower B, Wu AHB, Thompson PD. High carrier prevalence of deficient and null alleles of CYP2 genes in a major USA hospital: Implications for personalized drug safety. Personalized Medicine, 3(2), 131-137, 2006
9. Ruaño G, Bower B. The Pharmacogenomics of Warfarin (Coumadin) Administration. Connecticut Medicine, 70(4), 251-252, 2006
10. Holford TR, Windemuth A, Ruano G. Designing Physiogenomic Studies, Pharmacogenomics, 7(2): 157-158, 2006
11. Wang SJ, N Cohen, DA Katz, G Ruano, PM Shaw and B Spear. Retrospective validation of genomic biomarkers – what are the questions, challenges and strategies for developing useful relationships to clinical outcomes – workshop summary, The Pharmacogenomics Journal, March, 2006
12. Ruaño G, Thompson PD, Holford TR, Wu AHB, et al. Physiogenomic analysis links serum creatine kinase activities during statin therapy to vascular smooth muscle homeostasis, Pharmacogenomics Vol. 6, No. 8 (December), pp. 865-872, 2005
13. Ruaño, G, Seip, R .L., Bilbie, C., Zöllner, S., Miles, M., Zoeller, R., Visich, P., Gordon, P., Angelopoulos, T. J., Pescatello, L., Moyna, N., Tsongalis, G.J, Otvos, J., Ordovas, J.M., Thompson, P.D.: A common promoter polymorphism of the Apolipoprotein A1 gene affects exercise-induced changes in cholesterol distribution among HDL subfractions. Atherosclerosis 185: 65-69, 2006
14. Holford, T., Windemuth, A., Ruano, G. Personalizing public health. Personalized Medicine. 2(3): 239-249, 2005
15. Ruaño G, Zöllner S, Goethe JW. Drug-induced metabolic syndrome (DIMS) in psychiatry: a diagnostic need uniquely suited to pharmacogenomics. In: Wong SHY, Linder MW, Valdes R Jr, eds. Pharmacogenomics and proteomics: enabling the practice of personalized medicine. Washington, DC: AACC Press, 2006; 277–82.
16. Ruaño, G, Windemuth, A, Holford, T. Physiogenomics: Integrating systems engineering and nanotechnology for personalized health. In The Biomedical Engineering Handbook, 3rd Edition, Joseph D. Bronzino, editor, CRC Press Taylor and Francis, 28-1-28-9, 2006.
17. Ruaño, G. Quo Vadis personalized medicine? Personalized Medicine 2004. 1(1): 1-7
18. Ruaño, G. and Scherrrer RW. Genomas: Company Profile Personalized Medicine 2004. 1(1): 135-139
19. Ruaño, G, Collins, JM, Dorner, AJ, Wang, SJ, Guerdolini, R, Huang, SM. Pharmacogenomic data submission to the FDA: clinical pharmacology case studies. Pharmacogenomics 2004; 5(5):513-517.
20. Judson, R., Brain, C., Dain, B., Windemuth, A., Ruaño, G., Reed, C. New and confirmatory evidence of an association between APOE genotype and baseline C-reactive protein in dyslipidemic individuals. Atherosclerosis 177 2004; 345-351.
21. Winkelmann, BR, Hoffmann, MM, Nauck, M, Kumar, AM, Nandabalan, K, Judson, RS, Boehm, BO, Ruaño, G, März, W. Haplotypes of the cholesteryl ester transfer protein gene predict lipid-modifying response to stating therapy. The Pharmacogenomics Journal 2003; 3: 284-296.
22. Stephens JC, Schneider JA, Tanguay DA, Choi J, Acharya T, Stanley SE, Jiang R, Messer CJ, Chew A, Han JH, Duan J, Carr JL, Lee MS, Koshy B, Kumar AM, Zhang G, Newell WR, Windemuth A, Xu C, Kalbfleisch TS, Shaner SL, Arnold K, Schulz V, Drysdale CM, Nandabalan K, Judson RS, Ruaño G, Vovis GF. Haplotype variation and linkage disequilibrium in 313 human genes. Science 2001; 293:489-93.
23. Drysdale CM, McGraw DW, Stack CB, Stephens JC, Judson RS, Nandabalan K, Arnold K, Ruaño G, Liggett SB. Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness. Proc Natl Acad Sci USA 2000; 97:10483-8.
24. Tishkoff SA, Pakstis AJ, Ruaño G, Kidd KK. The accuracy of statistical methods for estimation of haplotype frequencies: an example from the CD4 locus. Am J Hum Genet 2000; 67:518-22.
25. Bentley KL, Li W, VannBerg FO, Choi JY, Yu J, Kao F, Ruaño G. Detailed Analysis of a 17q21 Microdissection Library by Sequence Bioinformatics and Isolation of Region-Specific Clones. Somat Cell Mol Genet 1997; 23:353-65.
26. Choi JY, Li WL, Kouri RE, Yu J, Kao FT, Ruaño G. Assignment of the acute phase response factor (APRF) gene to 17q21 by microdissection clone sequencing and fluorescence in situ hybridization of a P1 clone. Genomics 1996; 37:264-5.
27. Michalatos-Beloin S, Tishkoff SA, Bentley KL, Kidd KK, Ruaño G. Molecular haplotyping of genetic markers 10 kb apart by allele-specific long-range PCR. Nucleic Acids Res 1996; 24:4841-3.
28. Tishkoff S, Ruaño G, Kidd KK. Distribution and frequency of a polymorphic Alu insertion at the plasminogen activator locus in humans. Hum Genet 1996; 97:759-64.
29. Kidd KK, Ruaño G. Optimizing PCR. In: PCR-A Practical Approach, Volume 2 1995; G Taylor, M McPherson, D Hames (Eds.); IRL Press at Oxford University Press 1-22.
30. Li WL, Huckaby CS, Kouri RE, Ruaño G. Human Genomic Characterization of a Novel Locus-Specific Repetitive Sequence. Genomics 1995; 29:397-402.
31. Gaensslen RE, Berka KM, Pagliaro EM, Ruaño G, Messina D, Lee HC. Studies on DNA polymorphisms in human bone and soft tissues. Analytica Chimica Acta 1994; 288:3-16.
32. Ruaño G, Deinard AS, Tishkoff S, Kidd KK. Detection of DNA Sequence Variation via Deliberate Heteroduplex Formation from Genomic DNAs Amplified en masse in ‘Population Tubes’. PCR Methods and Applications 1994; 3:225-31.
33. Ruaño G, Lewis ME, Kouri RE. Cyclized Primer Extension: A Method for Simultaneous DNA Radiolabeling and Synthesis from Templates of Unknown Sequence. Anal Biochem 1993; 212:1-6.
34. Ruaño G, Lichter JB, Kidd KK. Normal DNA Sequence Variation: Detection Technologies and Implications. In: Genome Research in Molecular Medicine and Virology 1993, KW Adolph (Ed.), Academic Press.
35. Deinard AS, Ruaño G, Kidd KK. A dinucleotide repeat polymorphism at the HOX2B locus. Nucleic Acids Res 1992; 20:1171.
36. Gaensslen RE, Berka KM, Grosso DA, Ruaño G, Pagliaro EM, Messina D, Lee HC. A polymerase chain reaction (PCR) method for sex and species determination with novel controls for DNA template length. J Forensic Sci 1992; 37:6-20.
37. Rogers J, Ruaño G, Kidd KK.Variability in nuclear DNA among non-human primates: Application of molecular genetic techniques to intra-and inter-species genetic analyses. Am J Primatol 1992;27:93 105.
38. Ruaño G, Kidd KK. Modeling of Heteroduplex Formation During PCR from Mixtures of DNA Templates. PCR Methods and Applications 1992; 2:112-6.
39. Ruaño G, Pagliaro EM, Schwartz TR, Lamy K, Messina D, Gaensslen RE, Lee HC. Heat-soaked PCR: An Efficient Method for DNA Amplification with Applications to Forensic Analysis. BioTechniques 1992; 13:266-74.
40. Ruaño G, Rogers J, Ferguson-Smith AC, Kidd KK. DNA Sequence Polymorphisms within Hominoid Species Exceeds the Number of Phylogenetically Informative Characters for a HOX2 Locus. Mol Biol Evol 1992; 9:575-86.