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I am hiring creative and motivated individuals to join my lab in the NCI-Designated Lineberger Comprehensive Cancer Center at the University of North Carolina at Chapel Hill. Please visit the lab website thefrancolab.org for more information. The goal of my lab is to understand the molecular mechanisms that control the initiation and progression of cancer by focusing on the epigenetic and transcriptional programs that regulate these processes. We are particularly interested in studying the formation and function of transcriptional enhancers and the non-coding RNAs that are actively produced at enhancers, known as enhancer RNAs, that are involved in modulating several aspects of gene regulation. In addition, we aim to understand how transcriptional enhancers help orchestrate responses to external stimuli found in the tumor microenvironment. We address these research aims by using an interdisciplinary approach that combines state-of-the-art molecular and cellular techniques with powerful genomic and computational approaches
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