Ciencia Puerto Rico

Research title: Identification of Adenine/Uridine-Rich Elements (AREs) and its trans-acting factors on the post-transcriptional regulation of human Interleukin-3 on human cells

Project Description:  Human Interleukin-3 (hIL-3) is a lymphokine that is member of a class of transiently expressed mRNAs that harbor an Adenosine/Uridine-Rich Elements (ARE) in their 3' untranslated regions (3’-UTRs). The regulatory effects of AREs areoften mediatedby specific ARE-bindingproteins(ARE-BPs). The aim of the project is to understand how the interactions between ARE-BPs and AREs in the 3'-UTR of the IL-3 mRNA regulate its expression.