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I joined to the Ph.D. program in cellular and molecular biology in the Department of Biochemistry at Universidad Central del Caribe – School of Medicine (UCC), at 2010, conducting breast cancer research. Despite my vast experience in microbiology and biochemistry laboratories in the pharmaceutical industry, my laboratory research experience began on 2011 with my laboratory rotations, in my doctoral studies at UCC. Now, I’m working in my dissertation research project entitled “Role of Reishi on cell surface proteins and signaling modulation in Inflammatory Breast Cancer" which led me to be awarded with the Ruth L. Kirschstein National Research Service Awards For Individual Predoctoral Fellowships To Promote Diversity In Health-Related Research from National Institutes of Health (NIH). The main goal of this investigation is to validate the inhibitory role of Reishi on IBC progression via the inhibition of plasma membrane proteins and subsequent EGFR intracellular signaling events.
My mayor goal is to develop therapeutic agents that target cancer progression with fewer side effects. I want to commit my life to helping others and to advance the understanding in the cancer research field.
“Role of Reishi on cell surface proteins and signaling modulation in Inflammatory Breast Cancer"
The main goal of this investigation is to validate the inhibitory role of Reishi on IBC progression via the inhibition of plasma membrane proteins and subsequent EGFR intracellular signaling events. Plasma membrane proteins will be labeled via “stable isotope labeling with amino acids in cell culture” (SILAC) and analyzed via mass spectrometry (MS)-based quantitative proteomics. For studying the cell surface proteome we will compare non-treated IBC SUM-149 vs. non-cancerous mammary epithelial MCF-10A cells. To study Reishi effects on SUM-149 cell membrane protein inhibition, we will compare non-treated vs. Reishi treated cells. Moreover, to investigate the therapeutic potential of Reishi in IBC cells, focusing on EGFR or HER2 signaling cascades, the IBC SUM149 and SUM190 cells will be treated with lapatinib (EGFR and HER2 inhibitor), erlotinib (EGFR inhibitor) and/or Reishi to analyze the effects on cell proliferation, tumor spheroid formation, invasion, and EGFR/HER2 signaling to MAP/ERK and AKT pathways.
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