I study a rare inherited peripheral neuropathy caused by a mutation in one of the cation chloride cotransporters. Currently, it is unclear how a mutation in the transporter results in the development of peripheral neuropathy, and whether that damage occurs in the central or peripheral nervous system. To uncover some of the mechanisms in the development of this neuropathy, I will be utilizing mouse models to try to understand how the cotransporter functions in basal conditions, and if I can rescue the phenotype in various mouse models.