Welcome to CienciaPR, an expert and resource network for all who are interested in science and Puerto Rico.
I obtained my bachelors degree in biology from the University of Puerto Rico, Rio Piedras Campus, where I was a MARC fellow. I completed a PhD in Biomedical Sciences from the University of Tennessee-Oak Ridge. My postdoctoral training in cancer biology was done at the University of Cincinnatti, while my postdoctoral training in mouse cancer genetics was done at The Ohio State University. I was assistant professor at Emory University, Department of Radiation Oncology.
My laboratory studies the relationship between chromosome instability in breast cancers, particularly how centrosome amplification results in multipolar mitosis and defective cytokinesis, generating aneuploidy. Albeit most human tumors are aneuploid, the role of high levels of aneuploidy in cancer is still controversial. Specifically, we address how the Rb/E2F pathway acts as a master controller of centrosome amplification and mitotic dysfunction in cancer. Our latest work has identified several mitotic and centrosome regulators that mediate centrosom amplification and chromosome instability in breast cancer cells. We have published that the overexpression of these proteins correlates strongly with poor survival of breast cancer patients. We would like to know whether these mitotic proteins correlate with poor survival of breast cancer patients in African American and Hispanic populations, which are disproportionately affected by high-risk breast tumors, in particular Her2+ and triple-negative tumors.
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