Comparative genomics of Listeria species.
Enviado por Alberto Tierrez Martínez el
Título | Comparative genomics of Listeria species. |
Publication Type | Journal Article |
Year of Publication | 2001 |
Autores | Glaser, P, Frangeul, L, Buchrieser, C, Rusniok, C, Amend, A, Baquero, F, Berche, P, Bloecker, H, Brandt, P, Chakraborty, T, Charbit, A, Chetouani, F, Couvé, E, de Daruvar, A, Dehoux, P, Domann, E, Domínguez-Bernal, G, Duchaud, E, Durant, L, Dussurget, O, Entian, KD, Fsihi, H, García-del Portillo, F, Garrido, P, Gautier, L, Goebel, W, Gómez-López, N, Hain, T, Hauf, J, Jackson, D, Jones, LM, Kaerst, U, Kreft, J, Kuhn, M, Kunst, F, Kurapkat, G, Madueno, E, Maitournam, A, Vicente, JM, Ng, E, Nedjari, H, Nordsiek, G, Novella, S, de Pablos, B, Pérez-Diaz, JC, Purcell, R, Remmel, B, Rose, M, Schlueter, T, Simoes, N, Tierrez, A, Vázquez-Boland, JA, Voss, H, Wehland, J, Cossart, P |
Journal | Science |
Volume | 294 |
Issue | 5543 |
Pagination | 849-52 |
Date Published | 2001 Oct 26 |
ISSN | 0036-8075 |
Palabras clave | Adaptation, Physiological, Amino Acid Motifs, Bacillus subtilis, Bacterial Proteins, Base Composition, Carrier Proteins, Chromosomes, Bacterial, DNA, Bacterial, Gene Transfer, Horizontal, Genes, Bacterial, Genome, Bacterial, Genomics, Listeria, Listeria monocytogenes, Membrane Proteins, Sequence Analysis, DNA, Staphylococcus aureus, Transcription Factors, Virulence |
Abstract | Listeria monocytogenes is a food-borne pathogen with a high mortality rate that has also emerged as a paradigm for intracellular parasitism. We present and compare the genome sequences of L. monocytogenes (2,944,528 base pairs) and a nonpathogenic species, L. innocua (3,011,209 base pairs). We found a large number of predicted genes encoding surface and secreted proteins, transporters, and transcriptional regulators, consistent with the ability of both species to adapt to diverse environments. The presence of 270 L. monocytogenes and 149 L. innocua strain-specific genes (clustered in 100 and 63 islets, respectively) suggests that virulence in Listeria results from multiple gene acquisition and deletion events. |
DOI | 10.1126/science.1063447 |
Alternate Journal | Science |
PubMed ID | 11679669 |