Effect of vasopressin and protein kinase C inhibitors on junctional conductance in isolated heart cell pairs.
Enviado por Walmor Carlo De Mello el
PDF version| Título | Effect of vasopressin and protein kinase C inhibitors on junctional conductance in isolated heart cell pairs. |
| Publication Type | Journal Article |
| Year of Publication | 1991 |
| Autores | De Mello, W |
| Journal | Cell Biol Int Rep |
| Volume | 15 |
| Issue | 6 |
| Pagination | 467-78 |
| Date Published | 1991 Jun |
| ISSN | 0309-1651 |
| Palabras clave | Alkaloids, Animals, Cells, Cultured, Electric Conductivity, Enzyme Activation, Heart Ventricles, Intercellular Junctions, Myocardium, Protein Kinase C, Rats, Signal Transduction, Staurosporine, Vasopressins |
| Abstract | The effect of vasopressin on junctional conductance (gj) in isolated heart cell pairs was investigated. The results indicated that vasopressin (60 nM) causes a decrease in gj of 53% (S.E. +/- 5) (n = 10) within 15 sec. of its administration to the bath. The effect of vasopressin was dose-dependent and was suppressed by staurosporine (50 microM)--a potent inhibitor of protein kinase C. Inhibitors of protein kinase C by themselves increased gj. The results indicate that protein kinase C plays an important role in the control of gj in heart muscle. |
| Alternate Journal | Cell Biol. Int. Rep. |
| PubMed ID | 1742794 |
| Grant List | HL 34148 / HL / NHLBI NIH HHS / United States RR 08102 / RR / NCRR NIH HHS / United States |
