A job posting for a South San Francisco biotech company...
Enviado el 27 enero 2006 - 6:50pm
Este artículo es reproducido por CienciaPR con permiso de la fuente original.
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KAI Pharmaceuticals has an open Scientist position in cellular and
> molecular biology. KAI (kinase activators/inhibitors) is a company
> that
> was founded on strong research and pre-clinical work. In some of
> these
> studies it was found that peptides, which may be conjugated to
> cellular
> transduction domains, are able to have strong pharmacological
> activities
> in animal models of myocardial ischemia, and stroke. The
> pharmacological
> portions of these peptides (non transduction segments) target the
> interaction of activated PKC with a sub-cellular scaffolding receptor,
> which is a critical interaction in transducing PKC signaling. Each
> PKC
> isozyme has distinct subcellular compartments and seemingly distinct
> receptors. Peptides have been made which either specifically
> activate or
> inhibit many isozyme activities in this family of signaling kinases.
> More information may be found on our web site. We have a need to
> establish cell based assays to measure structure activity
> relationships
> and to monitor potential relevance to pathologies which manifest
> disease
> states (e.g. systems which monitor inflammation or tumor progression).
> The goal of my group is to investigate, establish, validate and
> execute
> outstanding assays for each of the 8 PKC isozymes and to utilize these
> systems to direct better modulator activities, identify secondary
> targets
> and model disease pathologies. We are looking for very talented,
> focused, goal driven individuals with a strong track record of
> success,
> creativity, and strong interpersonal skills. If you feel as though
> this
> position interests you and you are able to meet the requirements,
> please
> forward to:
>
> Jim Tomlinson, Ph.D.
> Senior Scientist, Cell Biology
> KAI Pharmaceuticals, Inc.
> 270 Littlefield Avenue
> South San Francisco, CA 94080
> Office: (650) 244-1119
> jim.tomlinson@kaipharma.com
> http://www.kaipharmaceuticals.com/
>
>
> Job description to follow:
>
> Scientist Research
>
> Responsibilities:
> The successful candidate will be responsible for identifying key
> cellular
> readouts of protein kinase C signaling and validating their utility
> for
> both drug discovery and advancing therapeutic strategies. The
> candidate
> will also contribute to objectives being pursued by other team
> members,
> including assay development, compound evaluation, biomarker
> research and
> animal efficacy studies.
>
>
> Requirements:
> PhD in a biological science, with 4-6 years relevant experience,
> preferably in the biotechnology industry. A strong background in
> signaling biology and drug discovery is required as well as a high
> proficiency in cell biology and molecular biology techniques.
> Demonstrated experience using multi-color flow cytometry (FACS)
> technology to study intracellular signaling pathways, and biomarkers,
> including multiparameter and multiplex analysis, is a plus.
> Creativity,
> demonstrated technical proficiency, and maintaining familiarity with
> relevant literature is expected. Must be flexible and unafraid to
> try new
> approaches or methods, with ability to choose proper strategies and
> techniques with minimal supervision. Willingness to participate
> thoroughly in scientific discourse is essential. A research
> background in
> cardiovascular disease, inflammation or oncology is preferred.